摘要
目的探讨盐酸戊乙奎醚对心肺复苏术后患者的脑氧供需失衡和神经功能状况的影响。方法选择40例心肺复苏初步成功的病人,采用临床神经功能综合评分(NFCS)对其神经功能状况进行评定,试验组(25例)给予盐酸戊乙奎醚4mg/24h,微量泵持续泵入,首量加倍;对照组(15例)未使用盐酸戊乙奎醚,其余治疗方案同试验组。观察期间监测病人动脉血氧含量(CaO2),颈内静脉血氧饱和度(SjvO2)、氧含量(CjvO2)及动脉血乳酸盐含量(ABL)和颈内静脉血乳酸盐含量(JVBL),并计算脑氧摄取率(CERO2),桡动脉-颈内静脉血乳酸盐差值(DLA-V)。结果在心肺复苏术后第72h,NFCS评分试验组明显较对照组高(P<0.01);与对照组相比,在48、72h两个时段,试验组氧代谢指标CjvO2、SjvO2、ABL、JVBL、DLA-V显著降低,CERO2显著增高(P<0.05或P<0.01)。结论盐酸戊乙奎醚可改善心肺复苏术后患者的脑组织缺氧和神经功能状况。
Objective To evaluate the effects of penehvclidine hydrochleride （PH） on nerve function and cerebral oxygen delivery- consumption disequilibrium in patients survived from cardiopulmonary resuscitated （CPR）. Methods The questionnaires of nerve functional comprehensive score （NFCS） were employed to evaluate the nerve functional status in 40 patients who were survived from CPR. These patients were randomly divided into 2 groups. The patients in group C （n= 15） were treated with combined therapy, those in group T （n = 25） were treated with combined therapy plus PH 4mg/24 h intrave- nous bolus. Content of arterial oxygen （CaO2）, jugular venous oxygen saturation （SjvO2）, content of jugular venous oxygen （CjvO2）, arterial blood lactate （ABL）, and jugular venous blood lactate （JVBL） were monitored. Cerebral oxygen extraction rate （CERO2） and the difference of radial arterial and jugular venous blood lactate （DL∧-∨ ） were calculated in both groups. Results NFCS was significantly higher in the group T than that in the group C after 72 h （P〈 0.0l）. CjvO2, SjvO2, ABL, JVBL, and DL∧-∨ were significantly lower and CERO2 was significantly higher in the group T than those in the group C both during 48 h and 72 h after treatment （P〈 0.05）. Conclusions Penehvclidine hydrochloride could improve the nerve function and cerebral oxygen delivery- consumption disequilibrium in patients survived from CPR.
出处
《实用预防医学》
CAS
2007年第6期1849-1851,共3页
Practical Preventive Medicine
关键词
盐酸戊乙奎醚
脑复苏
脑氧需求
神经功能状况
Penehvclidine hydrochloride
Cerebral resuscitation
Cerebral oxygen consumption
Nerve function status
