摘要
【目的】观察烟酰胺治疗血液透析患者高磷血症的疗效。【方法】采用单盲、有对照的完全随机化方法将48例维持性血液透析患者分为实验组和对照组,均进行常规血液透析,实验组加用烟酰胺,观察治疗期内血钙、血磷、甲状旁腺激素(iPTH)的动态变化。【结果】实验组血磷水平逐渐下降,4个不同时间点的组间比较差异具有显著性(P<0.01);各时间点血磷水平与对照组比较,差异具有显著性(P<0.05)。实验组和治疗组血钙水平无明显改变。实验组血钙磷乘积逐渐下降,但与治疗前比较,差异无显著性(P>0.05);各时间点血钙磷乘积与对照组比较差异无显著性(P>0.05)。实验组血iPTH水平从治疗后30 d开始逐渐下降,与治疗前比较,差异具有显著性(P<0.01);治疗30 d后各时间点血iPTH水平明显下降,与对照组比较,差异具有显著性(P<0.05)。【结论】烟酰胺可有效控制血液透析患者高磷血症。
[Objective]To observe the therapeutic effect of nicotinamide on hyperphosphatemia in maintenance hemodialysis patients. [Methods]Fifty two patients were divided into the experimental group and the control group at random. All patients were treated with the conventional hemodialysis and nicotinamide was added to the experimental group. Blood samples were collected for measurement of serum calcium, phosphorus, parathyroid hormone （iPTH） and the calcium-phosphate product were calculated. [Results] Serum phosphate level was gradually decreased with nicotinamide treatment（ P 〈0.01）and there was a significant difference compared with that in control group（ P 〈0, 05）, Serum calcium and the calcium-phosphate product in both experimental and control group were unchanged during nicotinamide treatment（ P 〉0.05）. After thirty days of treatment, the iPTH levels decreased with nicotinamide treatment and there was a significant difference compared with that in control group（ P 〈0.01）. [Conclusion] Nicotinamide can effectively ameliorate hyperphosphatemia in maintenance hemodialysis patients.
出处
《医学临床研究》
CAS
2007年第12期2122-2124,共3页
Journal of Clinical Research
