期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

血管内皮细胞生长因子及其受体与白血病 被引量：1

Leukemia and VEGF as well as its Receptor
暂未订购
导出
摘要 血管新生在白血病发生、发展过程中起着重要的作用,血清血管内皮生长因子(VEGF)水平能够在一定程度上解释白血病血管新生现象,VEGF是作用最强、特异性最高的血管新生调节因子,白血病细胞不仅分泌VEGF还不同程度的表达VEGF受体,VEGF在刺激白血病细胞增殖、迁移中发挥重要作用。动态检测血清VEGF水平可在一定程度上了解白血病的状态和体内白血病细胞的总负荷量,对白血病的疗效及预后判断有一定的指导意义。文章综述VEGF及其受体与白血病的关系。 Angiogcnesis may play a key role in the genesis and development of leukemia. Serum VEGF level can sumewhat explain the phenomena of angiogenesis. VEGF is a kind of regulatory faetor with highest effect and highest specificity. Leukemic cells not only can secrete VEGF, but also can express VEGTR. VEGF play an important role in stimulating the proliferation and metastasis of leukemic cells. Detecting serum VEGF in dynamic state can recognize the condition of leukemia and the total loading dose of leukemic cells, which have somewhat instructive significance for the effective and prognostic judgement. This article reviews the relationship between leukemia and VEGF and its receptor.
作者 孙福金 吴广胜
机构地区 新疆石河子大学医学院第一附属医院血液科
出处 《医学综述》 2008年第2期175-177,共3页 Medical Recapitulate
基金 石河子大学自然基金项目(YL2006-R17)
关键词 白血病 血管生成 血管内皮生长因子 Leukemia Angiogenesis Vascular endothelia growth factor
分类号 R733.7 [医药卫生—肿瘤]
  • 相关文献

参考文献18

  • 1Leung DW,Cachianes G.Kuang WJ,et al.Vascular endothelial growth factor is a secreted angiogenic Mitogen[J].Science,1989,246(4935):1306-1309.
  • 2Dias S,Hattori K,Zhu Z,et al.Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration[J].J Clin Invest,2000,106(4):511-521.
  • 3Dias S,Hattori K,Heissig B,et al.Inhibition of both paracrine and autocrine VEGF/VEGFR-2 signaling pathways is essential to induce longterm remission of xenotranspanted human leukemias[J].Proc Natl Acad Sci USA,2001,98(19):10857-10862.
  • 4Fiedler W,Graeven U,Ergün S,et al.Vascular endothelial gowth factor,a possible paracrine growth factor in human acute myeloid leukemia[J].Blood,1997,89(6):1870-1875.
  • 5Aguayo A,Estey E,Kantarjian H,et al.Celluar vascular endothelial growth factor is a predictor of outcome in patients with acute myeloid leukemia[J].Blood,1999,94(11):3717-3721.
  • 6Ghannadan M,Wimazal F,Simonitsch I,et al.Immunohemical detection of VEGF in the bone marrow of patient with acute myeloid leukemia.Correlation between VEGF expression and the FAB category[J].Am J Clin Pathol,2003,119(5):663-671.
  • 7Verstovsek S,Kantarjian H,Manshonri T,et al.Prognostic significance of cellular vascular endothelial growth factor expression in chronic phase chronic myeloid leukemia[J].Blood,2002,99(6):2265-2267.
  • 8Koomagi R,Zintl F,Sauerbrey A,et al.Vascular endothelial growth factor in newly diagnosed and recurrent childhood acute lymphoblastic leukemia as measured by real time quantitative polymerase chain reaction[J].Clin Cancer Res,2001,7(11):3381-3384.
  • 9Chen H,Treweeke AT,West DC,et al.In vitro and in vivo production of endothelial growth factor by chronic lymphocytic leukemia cells[J].Blood,2000,96(9):3181-3187.
  • 10Molica S,Vitelli G,Levato D,et al.Increased serum levels of vascular endothelial growth factor predict the risk of progression in early B-cell chronic lymphocytic leukaemia[J].Br J Haematol,1999,107(3):605-610.

二级参考文献15

  • 1Bellamy WT,Richter L,Frutiger Y,et al.Expression of vascular endothelial growth factor and its receptors in hematopoietic malignancies[].Cancer Research.1999
  • 2Cheson BD,Zwiebel JA,Dancey J,et al.Novel therapeutic agents for the treatment of myelodysplastic syndromes[].Seminars in Oncology.2000
  • 3de Bont ES,Rosatu S,Jacobs S,et al.Increased bone marrow vascularization in patients with acute myeloid leukemia: a possible role for vascular endothelial growth factor[].British Journal of Haematology.2001
  • 4Singhal S,Mehta J,Eddlemon P,et al.Marked anti-tumor effect from anti-angiogenesis (AA) therapy with thalidomide in high risk refractory multiple myeloma[].Blood.1998
  • 5Pruneri G,Bertolini F,Soligo D,et al.Angiogenesis in myelodysplastic syndromes[].British Journal of Cancer.1999
  • 6Perez-Atayde AR,Sallan SE,Tedrow U,et al.Spectrum of tumor angiogenesis in the bone marrow of children with acute lymphoblastic leukemia[].American Journal of Pathology.1997
  • 7Padro T,Ruiz S,Bieker R,et al.Increased angiogenesis in the bone marrow of patients with acute myeloid leukemia[].Blood.2000
  • 8Ferrara N.Role of vascular endothelial growth factor in regulation of physiological angiogenesis[].American Journal of Physiology Cell Physiology.2001
  • 9Aguayo A,Kantarjian H,Manshouri T et al.Angiogenesis in acute and chronic leukemias and myelodysplastic syndromes[].Blood.2000
  • 10Aguayo A,Estey E,Kantarjian H,et al.Cellular vascular endothelial growth factor is a predictor of outcome in patients with acute myeloid leukemia[].Blood.1999

共引文献40

同被引文献10

  • 1孔佩艳,郭朝华,罗成基.趋化因子SDF-1对淋巴细胞白血病细胞的作用[J].免疫学杂志,2001,17(z1):101-103. 被引量：1
  • 2周勇,耿美玉,杜冠华.低密度蛋白质芯片在医药研究中的应用[J].中国药理学通报,2006,22(4):389-393. 被引量：1
  • 3潘敬新,郭健欣,陈志哲,陈君敏.几种反应性氧代谢物逆转剂免疫佐剂作用的比较[J].免疫学杂志,2007,23(4):421-423. 被引量：3
  • 4Tao SC, Chen CS, Zhu H. Applications of protein microarray technology [J]. Comb Chem High Throughput Screen, 2007, 10 (8) : 706-718.
  • 5van der Kolk DM, de Vries EG, Muller M, et al. The role of drug efflux pumps in acute myeloid leukemia [J]. Leuk Lymphoma, 2002,43 (4) : 685-701.
  • 6Valera ET, Scrideli CA, Queiroz RG, et al. Multidrug resistance protein (MDR-1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) gene expression in childhood acute lymphoblastic leukemia [J]. Sao Paulo Med J,2004, 122(4): 166-171.
  • 7Ross DD. Novel mechanisms of drug resistance in leukemia [J].Leukemia, 2000, 14 (3): 467 - 473.
  • 8Kijowski J,Baj Krzyworzeka M,Majka M,et al. The SDF-1-CXCR4 axis stimulates VEGF secretion and activates integrins but does not affect proliferation and survival in lymphohematopoietic cells [J]. Stem Cells,2001, 19 (5): 453-466.
  • 9Bruserud O, Ulvestad E. Expression and release of adhesion molecules by human acute myelogenous leukemia blasts[J]. Leuk Res, 1999,23(2): 149-157.
  • 10Nozawa F, Itami A, Saruc M, et al. The combination of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/Apo2L) and Genistein is effective in inhibiting pancreatic cancer growth[J]. Pancreas, 2004,29 (1) : 45-52.

引证文献1

二级引证文献3

医学综述
2008年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部