摘要
目的:探讨眼针对血管性痴呆(VD)大鼠学习记忆障碍及血清中降钙素基因相关肽(CGRP)及内皮素(ET)的影响。方法:4-血管阻断法制成血管性痴呆大鼠模型。取眼针肝区、心区、肾区。共治疗30天,并与西药尼莫通相对照。实验前后分别进行Y-型迷宫测试及实验结束后腹腔静脉取血测量血清中CGRP和ET。结果:与对照组比较,模型组大鼠学习记忆明显障碍,眼针组、尼莫通组学习记忆能力明显改善,与模型组比较(P<0.01)。模型组与对照组相比,眼针组、尼莫通组与模型组相比CGRP和ET变化有显著差异(P<0.01)。结论:眼针能改善VD大鼠学习记忆障碍及调节血清中降钙素基因相关肽(CGRP)及内皮素(ET)两者的平衡,从而减轻缺血再灌注损伤。
Objective： To investigate the effects of eye acupuncture on learning disorder and dysmnesia, blood serum calcitonin gene-related peptide and endothelin in the rats with vascular dementia. Methods ：A rat model of vascular dementia was made by 4 vessel oceulusion. The liver, heart and kidney areas were selected for eye acupuncture. The treatment lasted 30 days. Western medicine Nimoton was used as a control. A Y type maze test and the changes of calcitonin gene related peptide and endothelin was performed before and after the experiment. Results： Learning disorder and dysmnesia were obvious in the model group as compared with the control group as compared with the control group. In the eye acupuncture and medication group of vascular dementia rats, learning disorder and dysmnesia were significantly abated as compared with the model group （ P 〈0.01 ）. The changes in the blood serum of calcitonin gene-related peptide and endothelin were significantly abated as compared with the model group （ P 〈 0.01 ）. Conclusion： Eye acupuncture can produce an improving effect on learning disorder and dysmnesia, and changes the level of blood serum calcitonin gene-related peptide and endothelin in experimental vascular dementia rats.
出处
《中华中医药学刊》
CAS
2008年第1期94-95,共2页
Chinese Archives of Traditional Chinese Medicine
基金
辽宁省科技厅自然基金资助项目(20052065)
关键词
眼针
CGRP
ET
血管性痴呆
学习记忆
eye acupuncture
calcitonin gene-related peptide
endothelin
vascular dementia
learning memory
