摘要
目的探讨黄精多糖对高脂血症实验兔动脉粥样硬化斑块的消退作用。方法将40只新西兰兔分为正常对照组（饲普通饲料）、模型组（饲胆固醇饲料）、辛伐他汀组（饲胆固醇饲料＋辛伐他汀）、黄精多糖组（饲胆固醇饲料＋黄精多糖），分笼喂养8周。分别于实验开始时、第2周末和第8周末，采用酶法检测血清总胆固醇（TC）、高密度脂蛋白胆固醇（HDL—C）、低密度脂蛋白胆固醇（LDL—C）、脂蛋白（a）[Lp（a）]水平。第8周末处死动物，光镜观察主动脉粥样硬化斑块消退情况。结果实验前各组血脂检测指标差异无统计学意义。实验第2周末（治疗前），模型组、辛伐他汀组和黄精多糖组血清TC分别为（10．2±1．6）、（11．0±1．8）、（11．2±1．9）mmol／L，LDL—C分别为（9．85±1．65）、（9．80±1．54）、（10．08±1．88）mmol／L，Lp（a）分另1为（656±106）、（700±151）、（666±111）mg／L均显著高于正常对照组[（1．3±0．3）mmol／L、（0．55±0．15）mmol／L、（106±15）mg／L，P〈0．01]。实验第8周末黄精多糖干预组TC、LDL—C、Lp（a）均显著低于治疗前[（6．0±2．0）mmol／Lvs（11．2±1．9）mmol／L、（4．25±1．35）mmol／Lvs（10．08±1．88）mmol／L、（55±14）mg／Lvs（666±111）mg／L，P〈0．01]，与模型组比较，黄精多糖组主动脉粥样硬化斑块基本消退。结论一定剂量的黄精多糖（1．6ml·kg^-1·d^-1）具有消退实验性高脂血症家兔主动脉粥样硬化斑块的作用。
Objective To study the effect of polygona-polysaccharose on the elimination of atheromatous plaque. Methods Thirty adult New Zealand rabbits were fed with high-fat and cholesterol forage for 8 weeks to establish hyperlipidemia animal models and then randomly divided into 3 equal groups： model group, simvastatin group receiving simvastatin orally, and polygona-polysaccharose group receiving polygona-polysaccharose orally. Ten rabbits were fed with normal food as control forage. At weeks 0, 2, and 8 the levels of total cholesterol （ TC）, high density lipoprotein cholesterol （HDL-C） ,low density lipoprotein cholesterol （ LDL-C）, and lipoprotein （a） [ Lp （a） ] were determined with enzyme method. At the end of the week 8, all rabbits were killed to observe the elimination of aorta atheromatous plaque by microscope. Results Before the experiment, there were no significant differences in the levels of serum lipids among all groups. At the end of week 2 （ before treatment）, the levels of serum TC of the model group, simvastatin group, and polygona-polysaccharose group were （ 10.2 ± 1.6） mmol/L, （ 11 ± 1.8） retool/L, and （ 11.2 ± 1.9） mmol/L respectively, the LDL-C levels of the 3 groups were （9.85 ± 1.65） mmol/L, （9.80 ± 1.54） mmol/L, and（ 10.08 ± 1.88） mmol/L respectively,the Lp （a） levels of the 3 groups were （656 ± 106） mmol/L, （700 ± 151 ） mmol/L, and（ 666 ±111 ） mmol/L respectively, all significantly higher than that of the control group [ （ 1.3 ± 0.3 ） mmot/L, （0.55 ± 0.15 ） mmol/L, and （ 106 ± 15 ） mg/L respectively, all P〈0.01]. At the end of week 8 （after treatment） , the levels of serum TC, LDL-C, and Lp（a） of the polygona-polysaeeharose group were （6.0 ±2.0） mmot/L, （4.25 ± 1.35） mmot/L, and （55 ± 14） mg/L respectively, all significantly lower than that at the end of week 2 [ （ 11.2 ± 1.9） mmol/L, （ 10.08 ± 1.88 ） mmol/L, and （666 ± 111 ） mg/L respectively, all P 〈 0. 01 ]. The aorta atheromatous plaques in the polygona-polysaeeharose group were basically eliminated compared with that in the model group. Conclusion Polygona-polysaceharose （ 1.6 ml ml·kg^-1·d^-1 ） has the effect of eliminating aorta atheromatous plaques.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2008年第2期127-130,共4页
National Medical Journal of China
基金
海南省自然科学基金重点资助项目（30223）
关键词
动脉硬化
高脂血症
黄精多糖
Arteriosclerosis
Hyperlipidemia
Polygona-polysaceharose
