摘要
本实验室观察到黑质具有升压效应。用L-谷氨酸钠微量注入黑质可使血压升高,此效应可被DA受体阻断剂氟哌啶醇(Halo)微量注入臂旁核加压区基本阻断。我们过去的工作证明延髓头端腹外侧区(RVL)及其内的α-受体中介臂旁核的加压效应,本实验将酚妥拉明注入RVL能明显衰减黑质的加压效应,而将Halo注入RVL加压区对黑质加压效应无明显影响。以上结果提示臂旁核-RVL(α-受体)加压系统参与黑质加压效应。
Besides its somatic motor and pain-regulation functions, we observed that substantia nig-ra (SN) had a pressor effect. Sodium glutamate-microinjection into SN produced a rise in blood pressure which could be blocked by haloperidol injection into bilateral parabrachial nucleus (NPB) but not by haloperidol injection into rostral ventrolateral medulla (RVL). Our previous study demonstrated that RVL and aaaaaaaaaaaaaaaa-adrenoceptors within it mediated the NPB-pre-ssor effect. The present study showed that bilateral injection of phentolamine into RVL attenuated the pressor effect of SN, but no effect on the pressor effect of SN by haloperidol ingec-tion NPB. These result suggest that the NPB-RVL (a-receptor) pressor system is involved in the pressor effect 6f SN.
出处
《动物学报》
SCIE
CAS
CSCD
1989年第3期294-299,共6页
ACTA ZOOLOGICA SINICA
基金
自然科学基金
关键词
臂旁核
延髓头端腹侧
黑质
Substantia nigra, Parabrachial nucleus, Rostral ventrolateral medulla, Pressor effect, Haloperidol,
