摘要
目的:探讨喉癌中△Np63蛋白表达及其与临床病理的关系。方法:应用免疫组化SP法检测喉癌和正常喉黏膜中△Np63蛋白的表达。结果:喉癌中△Np63的阳性表达率为75.0%,正常喉粘膜中的阳性表达率为15.0%,组间比较差异具有显著性(P<0.01)。阳性表达率与组织学分级有关(P<0.05)。结论:△Np63可能与喉癌的发生、分化和预后有关,可以作为喉鳞癌和腺癌鉴别诊断的依据。
Objective ： To investigate the expression of △Np63 protein, and the possible relationship between △Np63 expression and clinicopathological indices in laryngeal carcinoma. Methods. The expression of △Np63 was detected in 40 larynx cancer tissues by immunohischemical method（sp） and 20 normal larynx tissues as control. Results, The rate of expression of △Np63 protein in laryngeal carcinoma was 75. 0% （30/40）, in the normal larynx tissues was 15.0 % （3/20）, the difference was significant（P〈0. 01）;the positive ratio of the expression of △Np63 was significantly relate to histological differentiations of laryngeal carcinoma（P〈0.05）. Conclusion.. Over expression of △Np63 may be associated with the carcinogenesis and lower differentiation and prognosis, and it is also may be a diagnostic evidence for identifying laryngeal squamous carcinoma and adenocarcinoma.
出处
《实用临床医学（江西）》
CAS
2007年第12期9-10,共2页
Practical Clinical Medicine
关键词
喉癌
△NP63
免疫组化
laryngeal carcinoma
△Np63
immunohischemistry
