摘要
目的:探讨EEG双谱分析技术的临床应用价值,提供恰当的异丙酚镇静方法。方法:50例ASA Ⅰ～Ⅱ级下腹部手术患者,随机分5组,硬膜外麻醉效果确切后,首先静注负荷量异丙酚,之后微量泵连续静注维持镇静水平。监测数量化脑电图参数、病人镇静分数、血流动力学参数。结果:随镇静浓度升高,BIS和SEF降低(P<0.01),镇静分数升高,MAP降低,心率无明显变化。病人苏醒后BIS和SEF即刻升高(P<0.01)。异丙酚静注速度为3.6～5.4mg·kg^(-1)·h^(-1)时,BIS和SEF分别为76.3±2.8～67.6±5.8和16.7±6.9～14.5±6.6。镇静分数3～5分。呼吸及血流动力学变化小,镇静效果较理想。结论:数量化脑电图(BIS、SEF)能较准确地监测异丙酚的镇静深度及病人清醒状态。异丙酚静注速度为3.6～5.4mg·kg^(-1)·h^(-1)时,镇静效果理想。
Objective:Using bispectral analysis of quantitative EEG to assess the sedation level of propofol infusion.Method:Fifty patients undergoing low abdominal surgical procedures under continuous epidural anesthesia.Patients were allocated to recive one of five loading-dose propofol infusion schemes designed to establish stable condition covering a range of states between conscious sedation and anesthesia.Each patient's response to graded series of stimuli was recorded.The EEG was continuously recorded to obtain the bispectral index(BIS),spectral edge frequency (SEF),median frequency(MF). Hemodynamic parameters were also monitored.Result:With increasing propofol infusion rate, there was a progressive decrease in the BIS and SEF(P<0.01).Sedation scores increased in dose-dependent fashion.With recovery from the sedative effect of propofol,BIS and SEF was increased(P<0.01).Propofol infused at 3.6 to 5.4mg·kg^(-1)·h^(-1) produced a appropriate sedation level, BIS and SEF were 76.3±2.8 to 67.6±5.8 and 16.6 ±6.9 to 14.5±6,respectively,the sedation scores was 3 to 5.Conclusion:EEG-BIS and SEF appears to be a useful parameters for assessing propofol-induced sedation level and can predict the likelihood of patient's responding to verbal commends during propofol-induced sedation.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
1997年第9期520-522,共3页
Chinese Journal of Anesthesiology
关键词
异丙酚
双谱分析
脑电图
Bispectral analysis
Electroencephalography
Conscious sedation
Propofol
