摘要
目的探讨中国既往不安全有偿供血员HIV感染自然史及其影响因素。方法采用双向性队列研究方法，从国家艾滋病综合防治示范区中抽取6个省的10个县（区），选择所有2006年7月24日前发现并确认既往不安全有偿采血（浆）者HIV／AIDS病例，收集其感染、发病、死亡信息及影响因素。采用SPSS12.0统计软件分析。结果（1）在7551例HIV感染者中，典型进展者6533例（86．52％，其中AIDS患者4757例），快速进展者108例（1．43％），长期不进展者910例（12．05％）。（2）目前已经进展为AIDS者4865例（64．43％），AIDS中位潜伏期为9年（95％ CI：8．96-9．04）；至今累计未应用抗病毒药物治疗者1157例（占AIDS23．78％），其中死亡283例，这些未治疗的AIDS死亡者中位生存时间为6个月（95％CI：4-7），2、3年病死率分别为95％、99％。（3）AIDS潜伏期长短与性别、感染HIV时年龄无关（P〉0．05）；未治疗的AIDS患者生存时间长短与性别有关（P〈0．05），但与诊断AIDS时年龄、文化程度、婚姻无关（P〉0．05）。结论研究结果与UNAIDS提出的成年人慢速疾病进展规律比较，所得潜伏期略长而AIDS自然生存期较短，但与其他途径感染HIV人群潜伏期相近。
Objective Discussing the natural history and the influencing factors of HIV infection among former commercial blood and plasma donors engaged in unsafe blood donation practices in China. Methods Using ambispective cohort study, with data obtained from ten counties （districts） from six provinces in the National AIDS Control Demonstration Area. HIV / AIDS cases were found and confirmed prior to July 24, 2006 being former commercial blood. Plasma donors were selected and data regarding infection, incidence, death, and influencing factors was collected. Analysis was performed using SPSS 12.0 statistical analysis software. Results （1）In 7551 cases of HIV infection, there were 6533 typical progressors （ 86.52% , 4757 cases of AIDS）, 108 rapid progressors （ 1.43 % ）, 910 long-term non- progressors （ 12.05 % ） with 4865 cases progressed to AIDS （64.43 % ）. The median incubation period for HIV progression to AIDS was nine years （95 % CI：8.96-9.04）. （2） According to data, from a total of 1157 AIDS cases without ARV therapy （23.78 % of total AIDS cases）, there were 283 confirmed AIDS- related deaths, of which the median survival time was 6 months （95 % CI：4-7） and the two and three year fatality rates were 95% and 99%, respectively. （3） The duration of HIV incubation period was irrespective to gender and age at the time of HIV infection （P 〉 0.05）. Length of survival for untreated AIDS showed correlation to gender （P 〈 0.05） but no correlation with culture, marital status or age at the time of diagnosis of AIDS （P 〉0.05）. Conclusion Compared with the UNAIDS theory regarding slow disease progressors among adults, our study showed a longer AIDS incubation period and shorter outlook for untreated survival, but a similar incubation period for other routes of HIV infection.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2008年第1期9-12,共4页
Chinese Journal of Epidemiology
基金
基金项目：国家“十五”科技攻关课题资助项目（2004BA719A12）
卫生部艾滋病防治应用性研究课题资助项目（WA2003-03）
关键词
HIV感染
中位潜伏期
中位生存期
双向性队列研究
HIV infection
Median incubation period
Median survival time
Ambispective cohort study
