摘要
本文报道４８例重症感染病人，在使用地塞米松或维生素Ｃ后血清过氧化脂质（ＬＰＯ）的变化。治疗前所有病人的血清ＬＰＯ均明显高于正常（Ｐ＜０．０５），当滴入地塞米松或维生素Ｃ后，ＬＰＯ值则下降，而对照组则持续升高，提示地塞米松和维生素Ｃ能阻止重症感染病人的脂质过氧化反应。对比之下，地塞米松降低血清ＬＰＯ似较维生素Ｃ迅速。而早期使用地塞米松或维生素Ｃ阻断脂质过氧化的链锁反应可能会减轻自由基对生物膜的侵害。
The alterations of serum LPO were reported after using dexamethasone or vitamin C in 48 patients with critical infection.Before treatment the srum LPO in all patients were significantly higher than normal(P<0 05).After infusion of dexamethasone or vitamin C the LPO values decreased,while it in the control group continuously increased.It is concluded that both dexamethasone and vitamin C can prevent the peroxidation of lipid in the patients with critical infection,but the effect of dexamethasone was more rapid.It is possible to give dexamethasone or vitamin C early to block the chain reactions of lipid peroxide,it can abate the adrerse effects of free radical to biomenbrane.
出处
《临床麻醉学杂志》
CAS
CSCD
1997年第3期141-143,共3页
Journal of Clinical Anesthesiology
