摘要
对80例慢性呼吸衰竭病人和37例健康人的红细胞(RBC)膜带3蛋白结构、含量和阴离子转移功能、RBC内外血气和血中HCO_3^-、Cl^-进行了研究。结果提示:肺心病Ⅱ型呼吸衰竭病人带3蛋白阴离子转运蛋白的氨基酸组分无变化,但带3蛋白阴离子转运功能降低,HCO_3^-/Cl^-交换受限,红细胞内产生的大量HCO_3^-不能充分排出,使红细胞内pH(pHi)升高。RBC内相对偏碱对缓解高碳酸血症所引起的氧离曲线过度右移,具有重要意义。
The changes of structure and content of the erythrocyte membrane band 3 protein and its function of anion transport and blood gases inside and out of the erythrocyte were observed in 3 groups. Group Ⅰ type Ⅰ, respiratory failure (n=40); group Ⅱ, type Ⅱ respiratory failure (n=40) and control group (CG, n = 37). The results showed that structures of anion transport site of erythrocyte membrane band 3 protein might not change in the patients of cor pulmonale with type Ⅱ respiratory failure, but their anion transport function markedly decreased and HCO_3^-/Cl^- exchange was restricted. This prevented HCO_3^- from moving out of RBC and led to relative alkolosis in the red cells. This might benefit the oxygen dissociation curve which was moved extremely to the right by hypercapnia.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1997年第4期347-351,共5页
Chinese Journal of Pathophysiology
基金
国家自然科学基金 No 39470306
关键词
区带3蛋白质
呼吸衰竭
红细胞
PH值
Respiratory insufficiency · Pulmonale heart disease · Acid-base imbalance · Band 3 protein
