摘要
目的探讨节细胞神经母细胞瘤的病理形态特征、组织分型、预后及诊断要点。方法对3例节细胞神经母细胞瘤进行病理组织学观察和免疫组织化学标记并进行文献复习,对此病的临床病理特征进行详细的形态观察及分析。结果肿瘤特征为在神经母细胞瘤中出现较成熟的神经节细胞,免疫组织化学标记:NF(+).NSE(H).CgA(+),CD99(-),syn(-),S100(-),LCA(-)。结论节细胞神经母细胞瘤是一种罕见的恶性程度很高的混合型肿瘤,根据年龄及神经母细胞瘤所占比例和分化程度进行分型对治疗和预后有一定的意义。
Objective To explore the clinicopathologic features,histological classification,prognosis and diagnosis of ganglioneuroblastoma （GNB）. Methods Histopathologic appearance, immunohisfichemical stainings were observed and analyzed in three cases of GNt3. The associated literature were reviewed. Results The characteristics of GNB was detected ＂that there was gangliocytes in component of differentiated neuroblastic tumour cells. Immunohistichemical staining showed the tumor cells were positive for NF, NSE and CgA, and negative for S-100 protein, LCA, CD99 and Syn. Conclusions GNB is an uncommon tumour with poor outcome which composed of gangliocytes and neuroblastoma. To make a histological classification according to age, the ratio of neuroblastic tumour component and the differation of GNB will be very useful in clinical therapy and prognostic evaluation.
出处
《中国基层医药》
CAS
2007年第11期1787-1788,共2页
Chinese Journal of Primary Medicine and Pharmacy
