摘要
目的探讨经鼻双水平气道内正压通气(nBiPAP)对重叠综合征(OS)患者血浆内皮素-1(ET-1)含量的影响。方法实验分为两组:慢性阻塞性肺疾病(COPD)组20例;重叠综合征组25例,用放免法测定COPD组及重叠综合征患者BiPAP治疗前后血浆ET-1浓度变化。分析其与睡眠期血氧饱和度的相关性。结果(1)BiPAP治疗前重叠综合征患者血浆ET-1浓度明显高于COPD组;(2)BiPAP治疗后重叠综合征患者血浆ET-1浓度较治疗前下降,差异有统计学意义;(3)血浆ET-1浓度与睡眠期平均血氧饱和度呈负相关(r=0.4979,P<0.05)。结论经鼻双水平气道内正压通气为治疗重叠综合征的有效方法,其发挥作用可通过增加血氧饱和度,降低ET-1水平。
Objective To explore the effect of nBiPAP on ET-1 of patients with overlap syndrome. Methods Levels of ET-1 in plasma of 25 cases of OS,20 cases of COPD were analysed by radioimmunoassay,and ET-1 in OS was measured before and after treatment. The relationship between ET-1 with ,SaO2 during sleep was analyzed. Results （1）The ET-1 levels in plasma of OS group were significantly higher than those of COPD group before treatment（P〈 0.01 ）. （2） In OS group, the ET- 1 levels were significantly higher after treatment than those before treatment（ P〈 0.01 ）. （3）The ET-1 level in plasma had a significantly negative correlation with the SaO2 during sleep（ r = 0. 4979, P〈 0.05）. Conclusion The nBiPAP ventilation was an effective treatment for OS patient.
出处
《中国基层医药》
CAS
2007年第11期1774-1775,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
肺疾病
慢性阻塞性
重叠综合征
内皮缩血管肽类
正压呼吸
Pulmonary disease, chronic obstructive
Overlap syndrome
Endothlins
Positive- pressure respiration
