摘要
为阐明低密度脂蛋白（LDL）分子颗粒与动脉粥样硬化之间的内在关系，本文以胆固醇负荷家兔为动物模型，从血浆及动脉粥样硬化病灶内LDL的脂质生化学和超微形态学的角度对其进行了动态观察。结果显示，随着胆固醇负荷时间的增加，血浆LDL中的各项生化指标如：TC、TG、PL、LPO以及ApoB等的含量逐渐增加，动脉粥样硬化灶内LDL中除CE及SpotX百分比明显增加外，LDL分子颗粒也明显增大。这一结果提示，血浆及动脉壁内LDL分子颗粒的增大可能是引起动脉粥样硬化形成的原因之一。因此，限制脂类物质的过量摄入，减少脂质过氧化物的产生，可能是预防动脉粥样硬化性心、脑血管病的关键措施。
In order to understand the association of low density lipoprotein (LDL) with atherosclerotic formation, We observed the change of lipid biochemical and molecular ultrastructure of LDL- in plasma and atherosclerotic area in rabbits after cholesterol feeded. The results showed that the levels of total cholesterol(TC), triglceride(TG), phospholipids(PL), lipid peroxide(LPO) and apolipoprotein B(ApoB) in plasma were increased significantly and that the percentages of cholesterol ester(CE) and lipid peroxided of CE (Spot X) were increased significantly, and the molecular size of LDL was also enlarged in the atheromas as compared with that in the plasma. These results suggest that molecular size change of LDL may be one of the causes inducing atherosclerosis.
出处
《脑与神经疾病杂志》
1997年第4期195-198,共4页
Journal of Brain and Nervous Diseases
关键词
低密度脂蛋白
分子颗粒
动脉粥样硬化
病理
Cholesterol Feeding Molecular Size of Low Density Lipoprotein Atherosclerosis
