摘要
目的:观察碱化与非碱化丁哌卡因硬膜外阻滞的药效学与药动学。方法:选择ASA Ⅰ～Ⅱ级行下肢手术患者60例。随机分成两组,每组30例。均用0.75％丁哌卡因1.5mg/kg行硬膜外阻滞,对比观察麻醉效果,并对碱化组中的8例,对照组中的6例作药代动力学研究。结果:与对照组比,碱化组起效时间和阻滞完善时间短,镇痛时间长,感觉神经阻滞节段数多(P<0.01)。两组药代动力学指标无显著差异(P>0.05)。结论:碱化丁哌卡因用于硬膜外阻滞,其效果优于非碱化丁哌卡因。
Objective:To detect the pharmacokinetics and pharmacodynamis of alkalinization of bupivacaine for epidural blockade.Method:Sixty adult patients,ASA gradeⅠ-Ⅱ,were randomly divided into two groups,in groupⅠ(n=30)epidural blockade was induced with alkalinized bupivacaine (pH=6.47)while groupⅡ(n=30)with bupivacaine hydrochloride (pH=5.50). The onset time and the duration of analgesia of two groups and plasma concentrations of bupivacaine of eight patients in group Ⅰ and six patients in group Ⅱ were measured with high performance liquid chromatography.Result:The onset time of analgesia was shorter in group Ⅰ than that in group Ⅱ (P<0.01),while the duration of analgesia was longer in group Ⅰ than that in group Ⅱ (P<0.01). There was no significant differerce in pharmacokinetic parameters between two groups (P<0.05). Conclusion:The clinical effect of the alkalinized bupivacaine was better than that the bupivacaine hydrochloride.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
1997年第8期462-464,共3页
Chinese Journal of Anesthesiology
关键词
药效学
碱化
丁哌卡因
硬膜外阻滞
Pharmacodynamics
Anesthesia,epidural
Pharmaeokineties
Bupivaeaine
Alkalinization
