摘要
采用气相色谱法对7-氯-2-氧代庚酸乙酯产品进行纯度测定,同时分离并分析了其中主要的微量杂质,该杂质为7-氯-2-氧代庚酸乙酯生产过程中产生的副产物。采用气相色谱-质谱联用法对7-氯-2-氧代庚酸乙酯产品进行了分析,通过解析7-氯-2-氧代庚酸乙酯及其主要杂质的质谱数据推断出该杂质为6-氯己醛。
A gas chromatography method was employed to determine the purity of ethyl 7- chloro-2-oxohepanoate by area normalization method. Meanwhile, the main trace impurity, a by-product in ethyl 7-chloro-2-oxohepanoate was also separated and analyzed. To identify the structure of this main trace impurity, the product of ethyl 7-chloro-2-oxohepanoate was dissolved in ethyl acetate and analyzed by the gas chromatography-mass spectrometry meth- od. The structure elucidation of ethyl 7-chloro-2-oxohepanoate and its main trace impurity by spectral data were discussed in detail. The trace impurity is identified as 6-chloro caproaldehyde.
出处
《质谱学报》
EI
CAS
CSCD
2007年第4期233-236,共4页
Journal of Chinese Mass Spectrometry Society
关键词
7-氯-2-氧代庚酸乙酯
微量杂质
气相色谱-质谱
裂解途径
ethyl 7-chloro-2-oxohepanoate
trace impurity
gas chromatography-mass spectrometry （GC/MS）
fragment pathways
