摘要
目的：探讨以顺铂为基础的髂内动脉灌注化疗在宫颈癌治疗中的作用。方法：112例中晚期宫颈癌患者，双侧髂内动脉插管，以DDP为基础，辅以BLM、MMC和PYM等灌注化疗，最后以明胶海绵颗粒栓塞。结果：本组病例临床症状均有改善；Ⅰb2‖Ⅱb27例化疗后行手术治疗，完整切除病灶；巨块型癌80．4％（41／51）肿块缩小超过50％，3～4周后92．2％（47／51）宫颈外形可见；颈管型缩小超过50％病例占66．7％（10／15）；97．8％（45／46）溃疡型癌合并出血治疗后出血即刻停止；盆腔疼痛缓解率100％，下肢水肿缓解率100％。结论：以顺铂为基础的髂内动脉灌注化疗对中晚期宫颈癌有非常好的近期疗效，可作为提高治愈率和长期缓解率的常规治疗手段。
Objective：To evaluate the therapeutic effect of intra - internal iliac arterial infusion chemotherapy based on cisplatin （DDP） in the treatment of cervical cancer. Methods： After superselective catheterization of bilateral internal iliac arteries, 112 patients diagnosed as advanced cervical cancer received intraarterial infusion chemotherapy with different regimens based on cisplatin combined with bleocin （ BLM ）, mitomycin （ MMC ） or pingyangmycin （PYM） adjuvants, and embolization was performed with gelfoam particles after infusion chemotherapy. Results： Clinical symptoms of all cases were relieved after the treatment. 27 cases in stage Ⅰ b2 - Ⅱb successfully underwent radical hysterectomy with pelvic lymphadenectomy. 80.4% （41/51） patients with bulky cervical tumor had over 50% tumor regression and after 3 to 4 weeks the cervical shape emerged obviously in 92.2% （47/51） cases; Cervical tumor of 66.7% （10/15） canal type shrank more than half, and 97.8% （45/ 46） cases of crater type with bleeding responded well and vaginal bleeding disappeared immediately after embolization. Pelvic pain and lower limb edema in all cases were relieved completely or partially. Conclusion： Intraarterial infusion chemotherapy of internal iliac arteries can yield satisfactory short - term curative outcome. This treatment method should be recommended in the treatment of advanced cervical cancer for increasing cure rate and long - term effectiveness.
出处
《西北国防医学杂志》
CAS
2007年第6期419-421,共3页
Medical Journal of National Defending Forces in Northwest China
关键词
宫颈癌
化疗栓塞
治疗性
治疗效果
Cervical cancer
Chemoembolization,therapeutic
Treatment effectiveness
