摘要
目的探讨血浆5-羟色胺与突发性聋的关系,进一步了解突发性聋的发病机制。方法突发性聋患者46例,健康对照组34例,使用免疫放射测定法,分别测定入院时或入选时血浆5-羟色胺浓度,进行统计学分析,同时调查1周前的负性生活事件。结果突聋组血浆5-羟色胺显著高于对照组(P<0.01);突聋组发病前35例(76%)存在疲劳、心理压力和睡眠减少。结论突聋患者血浆5-羟色胺升高可能与焦虑抑郁的情绪、血小板活化有关;血浆5-羟色胺是否与突聋的严重程度、预后有关,有待进一步研究。
Objective To explore the relationship between plasma 5 - HT and patients with sudden deafness and the pathogenesis in sudden deafness. Methods 46 inpatients with sudden deafness as patient group, and 34 healthy as control group. They were determined the plasma 5 - HT concentration by immunoradiometric assay , then statistics analysis, and investigated negative life events in one week before admission. Results There is significant difference in 5 - HT concentration between two groups. In patient group, 35 eases（76% ） had anxiety , depression emotion and sleep disorder before attack. Conclusions The high level of the plasma 5 - HT concentration is probably one of the mechanisms in the patients of sudden deafness. Whether there is relationship between plasma 5 - HT concentration and the degree and prognosis of sudden deafness needs to be further studied.
出处
《医学研究杂志》
2007年第12期81-82,共2页
Journal of Medical Research
关键词
5-羟色胺
焦虑
抑郁
血小板活化
突发性聋
5 -hydroxytryptamine（5 -HT）
Anxiety
Depression
Platelet activation
Sudden deafness
