摘要
采用荧光偏振免疫分析法，对2003～2006年我院急性淋巴细胞白血病患者MTX血药浓度进行监测。通过对监测结果的统计分析发现，根据不同时间点的MTX血药浓度指导临床亚叶酸钙“解救”，MTX基本都能降至安全浓度范围内，表明MTX血液浓度监测可以减少其毒副作用的产生，对临床治疗有着重要意义。
The methotrexate （MTX） serum concentration of patients with acute lymphocytic leukemia in our hospital during 2003 - 2006 was monitored by fluorescence polarization immunoassay. According to statistical monitoring results at different time points, most of the MTX serum concentration rescued by calcium folinate could successfully drop to the safe range, and a decrease of toxic reactions was also observed. But we also noticed some problems from this statistics and analysis, and wish to improve and consummate them in the future.
出处
《药学与临床研究》
2007年第6期487-489,共3页
Pharmaceutical and Clinical Research
关键词
血药浓度监测
甲氨蝶呤
急性淋巴细胞白血病
解救
Serum concentration monitoring
Methotrexate
Acute lymphocytic leukemia（ALL）
Rescue
