摘要
通过对几个手性选择剂的初步筛选，最后分别用２，６－二－Ｏ－羧甲基－β－环糊精和谷氨酸－β－环糊精作为手性选择剂拆分了维拉帕米和异丙嗪的光学对映体。着重考察了缓冲溶液的ｐＨ、手性选择剂的浓度对对映体表观淌度差的影响，并研究了有机溶剂甲醇对毛细管电泳手性分离的影响。
Verapamil enantiomers could be baseline separated using 2, 6-di-O-carboxyl- methyl-β-cyclodextrin as the chiral selector, but the enantiomers of promethazine could only be partially resolved using glutamate-β-cyclodextrin as the resolving agent. The effects of pH and concentrations of the chiral selectors on the separation were investigated. The addi- tion of an organic modifier such as methanol to the background electrolyte deteriorated the enantioseparations.
出处
《分析化学》
SCIE
EI
CAS
CSCD
北大核心
1997年第7期832-834,共3页
Chinese Journal of Analytical Chemistry
