摘要
目的:探讨骨桥蛋白(OPN)在直肠癌中的蛋白水平表达的临床意义。方法:采用免疫组织化学两步法对80例直肠癌组织中的OPN表达进行检测。结果:OPN在直肠癌组织中的阳性表达率为60%,其中Dukes′A、B期患者和Dukes′C、D期患者分别为31.1%和80%(P<0.01);淋巴结转移组和无淋巴结转移组分别为72.4%和33.3%(P<0.01);肝转移组和无肝转移组阳性表达率分别为76.9%和41.8%(P<0.05)。Kaplan-Meier分析,OPN阳性表达者的生存时间和5年生存率显著低于OPN阴性表达者(P<0.01)。结论:OPN的表达与直肠癌的进展和转移关系密切,对判断预后具有重要意义。
Objective：To explore the clinical significance of osteopontin （OPN） protein expression in rectal cancer.Methods：The expression of OPN of 80 cases of rectal cancer were studied with immunohistoehemical two steps technique.Results：The expressive rate of OPN of rectal cancer was 60%.The expression of Dukes＇ A-B grade and of Dukes＇C-D grade were 31.1% and 80% respectively （P〈0.01）.The expression of lymph node metastasis and of no lymph node metastasis were 72.4% and 33.3%, respectively（P〈0.01）.The expression of liver metastasis and of no liver metastasis were 76.9% and 41.8%,respectively （P〈0.05）.The mean survival time and 5-year survival rate in cases with positive OPN expression were significantly shorter than that of cases with negative expression（P〈0.01）.Condusion：The expression of OPN was closely related to the development of rectal cancer ,and would be a valuable prognostic marker.
出处
《中日友好医院学报》
2007年第6期349-351,F0003,共4页
Journal of China-Japan Friendship Hospital
关键词
直肠癌
骨桥蛋白
免疫组织化学
预后
rectal cancer
osteopontin
immunohistochemistry
prognosis
