摘要
目的了解近5年来就诊于我院的胃癌患者相关流行病学资料的特点及变化趋势，为疾病的诊断与评估提供帮助。方法将2000年1月～2005年10月于我院住院治疗的胃癌患者（共计429例）列为研究对象，进行回顾性分析，对其一般资料、病理类型、发生部位、浸润深度等进行统计。以t检验分析确诊年龄与病理类型、发生部位、是否转移之间的相互关系；以，检验分析病理类型与发生部位、是否转移、抗幽门螺旋杆菌（H．pylori）抗体、H．pylori-CagA-IgG之间的相关性。结果①429例胃癌中，男性占73．6％（316例），女性占26．4％（113例）。平均年龄为62．48岁（19～93岁）。病理类型以低分化腺癌居多，占51．2％，印戒细胞癌占21．2％。发生部位以胃窦部居多，占45．7％，贲门胃底癌占11．9％。发病率无明显上升趋势。②在确诊年龄上，高度恶性组（低分化腺癌＋印戒细胞癌）（平均年龄61．41岁）与低中度恶性组（高分化腺癌＋中分化腺癌）（平均年龄64．82岁）存在显著性差异（P〈0．05）；胃体癌（59．60岁）与胃窦癌（63．0岁）存在显著性差异（P〈0．05）。转移组（61．73岁）与无转移组（61．05岁）无显著差异（P〉0．05）。③胃癌的病理类型与肿瘤部位、是否转移、H．pylori-CagA-IgG相关性：胃体癌组、已转移组、H．pylori-CagA-IgG阴性组恶性度高（P〈0．05）。病理类型与患者血清抗H．pylori抗体无明显相关（P〉0．05）。结论①胃癌多见于老年、男性患者，以低分化腺癌、胃窦部多见，印戒细胞癌有逐年发病增多的趋势，未见贲门癌发病率逐年上升趋势。②在胃癌患者中，病理类型恶性度较高者，相对较为年轻；发生于胃窦部者，年龄相对较大。是否已有转移与年龄无关。③发生于胃体部、已有转移、H．pylori-Ca-gA-IgG（-）者，胃癌恶性度较高。抗凡pylorl抗体与胃癌恶性度无关。
Objective To investigate the characteristics and changing tendency of epidemiologic data of patients with gastric cancer in our hospital in the past five years. Methods Four hundred and twenty nine patients with gastric cancer in our hospital had been selected from 2000.1 to 2005.10. The common information,pathologic type,location and infiltrating depth were studied. The relationship between age and pathologic type,location, metastasis were analysed by t test, and the relationship between pathologic type and location, metastasis, anti-H, pylori antibody,H, pylori-CagA-IgG by χ^2 test. Results ① Of the 429 patients,316 （73.6%） were male and 113 （26.4%） were female, with a mean age of 62.48 years （range, 19 -93 years）. Regarding pathologic type, the majority were low-differentiation adenocarcinoma （51.2% ） , and signet-ring cell carcinoma accounted for 21.2%. Gastric cancer arised in gastric antrum more often, accounting for 45.7%. The cancer of gastric cardia and fundus accounted for 11.9% , and the incidence of them had no increase. ② Regarding age, there was a significant difference between the high malignant group（low-differentiation adenocarcinoma and signet- ring cell carcinoma） and the low and moderate malignant group（high-differentiation adenocarcinoma and moderate-differentiation adenocarcinoma）; metastasis group and immetastasis group had no significanct difference. ③Gastric-body cancer group, metastasis group, H. pylori-CagA-IgG（ - ） group were more malignant （P 〈 0.05）. There wash＇ t a significant relationship between pathologic type and anti-H, pylori antibody （ P 〉 0.05 ）. Conclusions ① Gastric cancer has a higher incidence in old male . Low-differentiation adenocarcinoma and cancer in gasreic antrum have larger probability. Incidence of signet-ring cell carcinoma has increased year by year, whereas the incidence of gastric cardia cancer has no increase. ② Patients with high malignant ganstric cancer are younger;patients with tumor in gastric body are older. ③ Gastric cancer in patients with gastric body cancer or metastasis or H. pylori-CagA-IgG （ - ） was more malignant. There wasn＇ t a relationship between pathologic type and anti-H, pylori antibody.
出处
《胃肠病学和肝病学杂志》
CAS
2007年第6期525-527,共3页
Chinese Journal of Gastroenterology and Hepatology
关键词
胃癌
流行病学
Gastric cancer
Epidemiology
