摘要
目的:建立国内抗感染药规定日剂量(DDDChina)数据库,与世界卫生组织(WHO)制定的抗感染药DDD(DDDWHO)进行比较,以揭示国内、外抗感染药用量的差异。方法:通过WHO制定的抗感染药DDD得到DDDWHO,查阅国家食品药品监督管理局(SFDA)统一制定的各种抗感染药说明书获得DDDChina;对DDDChina、DDDWHO进行比较、计算,得到各种抗感染药的DDD绝对百分比(AP)。结果:206种抗感染药中,DDDChina>DDDWHO的有53种,DDDChina=DDDWHO的有61种,DDDChina<DDDWHO的有92种。AP≥200%的抗感染药有15种,AP≤50%的有23种。结论:206种全身用抗感染药中,25.73%的药品DDDChina>DDDWHO,这可能与近年来抗感染药的细菌耐受性增强有关。
OBJECTIVE：To establish a DDD（defined daily dose） database for the anti- infective agents used in China and to compare DDD in China（DDDChina） with that defined by WHO（DDDWHO） so as to reveal the difference between China and abroad in consumption quantity of anti- infective agents.METHODS：DDDWHO of anti- infective agents was obtained from the DDD defined by WHO and DDDChina was obtained by reviewing package inserts of anti - infective agents specified by State Food ＆ Drug Administration（SFDA） .Then the absolute percentages of the DDD of the anti - infective agents were derived by comparison between DDDChina and DDDWHO.RESULTS： Of the total 206 kinds of anti- infective agents, 53 showed DDDChina〉 DDDWHO, 61 showed DDDChina = DDDWHO, 92 showed DDDChina〈 DDDWHO, 15 showed an absolute percentage of DDD≥200%, and 23 showed an absolute percentage of DDD≤50%. CONCLUSION：Of the 206 kinds of systemic anti- infective agents, 25.73% showed DDDChina〉DDDWHO,which might be associated to the recent elevated bacterial tolerance.
出处
《中国药房》
CAS
CSCD
北大核心
2007年第35期2735-2739,共5页
China Pharmacy
关键词
日剂量
绝对百分比
抗感染药
分析
Defined daily dose（DDD）
Absolute percentage
Anti- infective agents
Analysis
