摘要
目的:研究肺癌组织中环氧化酶-2(COX-2)的表达及其与临床病理特征、预后的关系。方法:采用免疫组化SABC法检测58例肺癌组织及9例癌远旁正常肺组织中COX-2表达。结果:肺癌组织COX-2阳性表达为60.34%(35/58)较正常肺组织11.11%(1/9)差异有统计学意义(P<0.01);COX-2的表达与患者的TNM分期、淋巴结浸润显著相关(P<0.05),与患者的年龄、性别、吸烟状况、组织类型无关(P>0.05)。COX-2阳性表达组的生存率低于阴性表达组(P=0.001)。结论:COX-2在肺癌的发展、转移过程中有一定作用,COX-2可以作为肺癌的预后指标。
Objective： To observe the correlation between COX-2 expression in lung cancer tissues and the clinicopathological features of lung cancer patients and to evaluate its role as a prognosis marker. Methods： The expression of COX-2 was detected in 58 cases primary lung cancer tissues and 9 cases normal pulmonary tissues as control by immunohistochemical method. Results： There was significant difference of COX-2 expression 60.34% （35/58） in lung cancer and 11.11% （ 1/9 ） in normal pulmonary tissues （ P 〈 0.01 ）, COX-2 expression were correlated with lung cancer TNM classification and lymph node invasiveness （ P 〈 0.05 ）, and were not correlated with age, sex, smoking history, histology type of patients （ P 〉 0.05 ）. The positive COX-2 expression group had a shorter survival time than that in negative expression group（ P = 0. 001 ）. Conclusion ： COX-2 may play an important role in the development and invasiveness of lung canc- er,it might be a useful marker in the prognosis of lung cancer.
出处
《江苏大学学报（医学版）》
CAS
2007年第6期505-507,共3页
Journal of Jiangsu University：Medicine Edition
关键词
环氧化酶-2
肺癌
免疫组织化学
cyclooxygenase-2
lung cancer
immunohistochemistry
