摘要
目的探讨子综合征出血热患者血浆内毒素水平及其在病损中的作用。方法应用堂试剂Ⅱ号对60例肾综合征出血热内毒素水平进行定量检测，并分析其与病型、肾损、休克、预后的关系，以t检验和X2检验进行统计学分析。结果60例肾综合征出血热病人血浆内毒素水平（190、15±10821Eu·L-1)明显高于对照组(73．47±23．41Eu·L－1），且内毒素血症阳性率高达866％。除恢复期外各期内毒素水平和内毒素血症阳性革也高于对照组，尤以休克期、少尿期、多尿早期升高明显。重型、危重型内毒素水平高于其它临床类型。严重肾损、颅内出血患者内毒素水平显著增高。结论肾综合征出血热患者内毒素水平及内毒素血症阳性率显著增高，并与临床病型、休克发生、肾损严重程度、预后有密切关系。
To research the levels of plasma endo-toxin and its pathogenesis in patients with hemorrhag-ic fever with renal syndrome(HFR).Method The plasma endotoxin were measured with limulus lysate test with chromogenic substrate in 60 cases of HFRS, and the correlation wer analysed between the levels of plasma endotoxin and clinical manifestation, renal damage, shock and prognosis by t test and X2 test.Results The level of plasma endotoxin in 60 HFRS patiens (190. 15 ±108. 2Eu' L-1) was higher than that of control group(73. 47 ± 23. 41Eu、 L-1),and the endotoxiemia positive rate was 86. 6%. The plasma endotoxin level and endotoxiemia positive rate were obviously higher in all clinical phages(not includ convalescent period), especially in shock, uropenia and beginning urorrhngia pericd. The serum levels of en-dotoxin wee higher in sever type and fetal type and the patients with severe renal damage and cerebral hemorrhage.Conclusion The serum levels of endotoxin and positive rate of endotoxiemia are higher in HFRS pa-tients, and it could be correlation with the clinical type, shock, renal damage and prognosis.
出处
《新乡医学院学报》
CAS
1997年第2期112-114,共3页
Journal of Xinxiang Medical University
关键词
肾综合征出血热
内毒素
病理
hemorrhagic fever with renal syn-drome
endotoxin
pathopoesis
