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国产雷帕霉素药物洗脱支架对急性心肌梗死的疗效观察 被引量:2

The clinical effect of homemade rapamycin-eluting stent on acute myocardial infarction
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摘要 目的观察国产雷帕霉素药物洗脱支架(Partner)对急性心肌梗死(AMI)的临床疗效。方法将2005年5月至2006年8月天津武警医学院附属医院心内科116例AMI行急诊经皮冠状动脉介入治疗(PCI)的患者,依所置入支架不同,分为进口Cypher组(n=52)和国产Partner组(n=64)。观察两组患者住院及随访期间主要心脏不良事件(MACE)的发生和血管再狭窄情况。结果两组患者梗死相关动脉的分布差异无显著性意义。Cypher组置入支架55枚,Partner组置入支架64枚。所有患者急诊PCI手术均成功,住院及随访期间无MACE发生。Cypher组11例(21.15%)、Partner组18例(28.13%)完成了6个月冠脉造影随访,再狭窄率均为0。结论国产雷帕霉素药物洗脱支架应用于AMI治疗安全、有效。 Objective To study the clinical effect of homemade rapamycin-eluting stent on acute myocardial infarction (AMI). Methods A total of 116 AMI patients who received emergency PCI were divided into two groups, the Cypher group ( n = 52 ) and the Partner group ( n = 64). There was no obvious difference in ages, female ratio, smoking, hypertension,hyperlipidema and diabetes between the two groups. The MACE and the restenosis were the targets we wanted to observe. ResuRs The emergency PCI were all successful. Fifty-five Cypher stents and sixty-four Partner stents were planted. The MACE was 0 during, in-hospital and the follow-up. Eleven patients in Cypher group (21.15%)and eighteen patients in Partner group (28. 13% )underwent coronary angiography re-examination at the 6 months' post-stenting,the restenosis both being 0. Conclusion The homemade rapamycin-eluting stent is safe and effective in AMI.
出处 《中国实用内科杂志》 CAS CSCD 北大核心 2007年第24期1940-1941,共2页 Chinese Journal of Practical Internal Medicine
关键词 支架 急性心肌梗死 Stents Acute myocardial infarction
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参考文献4

  • 1Degeare VS, Dangas G, Stone GW, et al. Interventional procedures in acute myocardial infarction[J]. Am Heart J,2001,141 (1) :15 - 24.
  • 2Stone GW, Gfines CL, Cox DA, et al. Comparison of angioplasty with stenting, with or without abciximab, in acute myocardial infarction[ J]. N Engl J Med,2002,346( 13 ) :957 - 966.
  • 3Moses J W, Leon MB, Popma J J, et al. Sirolimus-eluting stents versus standard stents in patients with stenosis in a native coronary artery[J], N Engl J Med,2003,349(14) :1315 - 1323,
  • 4Lemos PA, Saia F, Hofma SH, et al. Short and long-term clinical benefit of sirolimus-eluting stents compared to conventional bare stents for patients with acute myocardial infarction [ J ]. J Am Coil Cardiol,2004,43 (4) :704 - 708.

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