摘要
目的:通过对2型糖尿病阴虚证患者、甲亢病阴虚证患者一氧化氮合酶(NOS)mRNA表达的检测,探讨NOS活性与阴虚证的关系及意义。方法:分别检测2型糖尿病阴虚证患者、甲亢病阴虚证患者及正常对照组NOSmRNA的表达,并进行统计学分析。结果:糖尿病阴虚证患者、甲亢病阴虚证患者NOSmRNA的表达均显著强于正常对照组,而阴虚证两组间无显著差异。结论:2型糖尿病和甲亢病患者的NOSmRNA可能对阴虚证有重要意义,NOS基因表达增强可能是阴虚证的病理基础之一。
Objective:To probe the pathological foundation and essence of Yin deficiency syndrome in TCM by investigating the expressions of NOS mRNA of the patients diagnosed as Yin deficiency syndrome in both non-insulin-dependant diabetes mellitus(NIDDM)and hyperthyroidism.Methods:The expressions of NOS mRNA were detected in Yin deficiency syndrome patients of NIDDM,Yin deficiency syndrome patients of hyperthyroidism and control group,respectively.Finally the all determination results were analyzed with statistical method.Results:The expressions of NOS mRNA in both Yin deficiency groups are heightened than those in control group(P<0.01),however,there is no significant difference between these two Yin deficiency groups.Conclusion:NOS activity level in the patients suffering from NIDDM and hyperthyroidism are possibly significant with Yin deficiency syndrome,the heightened expression of NOS mRNA is possibly associated with occurrence of Yin deficiency syndrome.
出处
《中医药信息》
2007年第6期38-39,共2页
Information on Traditional Chinese Medicine
基金
湖北中医学院校基金资助课题(2003)
关键词
糖尿病
甲状腺功能亢进症
阴虚证
一氧化氮合酶
Diabetes mellitus(DM)
Hyperthyroidism
Yin deficiency syndrome
Nitric Oxide Synthetase(NOS)
