摘要
慢性阻塞性肺疾病（COPD）气道炎症是重要的病理基础,它不仅是气道重构的开始而且对肺血管炎症与重构有重要影响。长期以来强调低氧因素在肺血管炎症中的作用,现发现无缺氧的轻度COPD患者甚至肺功能正常的吸烟者肺血管和外周气道均出现了炎症和重构。在COPD早期肺血管炎症与外周气道炎症是否就已同时启动？它们之间有何联系？本文收集近年来国内外研究,就COPD气道炎症与肺血管炎症的相关性作一简要综述。
The inflammatory reaction in airway of chronic obstructive pulmonary disease（COPD） is the important pathological fundament.It is not only the origination of the remodeling in airways but also has the important effect on pulmonary vascular inflammation and remodeling.The role of hypoxia was emphasized in pulmonary vasculature long before.But now,the inflammation and remodeling in pulmonary vasculature and peripheral airways in mild COPD patients,even the smokers with normal pulmonary function have occurred without hypoxia.Whether the inflammatory reaction in airway and pulmonary vasculature starts at the same time in the early stage of COPD？ What is their relationship？ This article assembles internal and foreign researches in recent years to make a concise review on the relationship between airway inflammation and pulmonary vascular inflammation in COPD.
出处
《国际呼吸杂志》
2007年第23期1796-1799,共4页
International Journal of Respiration
基金
广西医疗卫生重点资助基金项目（200401）
广西青年科学资助基金项目（0728056）
关键词
慢性阻塞性肺疾病
气道炎症
肺血管炎症
Chronic obstructive pulmonary disease
Inflammatory reaction in airway
Inflammatory reaction in pulmonary vasculature
