摘要
用ＧｎＲＨａ－ＦＳＨ－ｈＭＧ－ｈＣＧ方案控制性超排卵进行体外受精与胚胎移植（ＩＶＦ－ＥＴ）治疗７８例不孕患者，在ｈＣＧ注射前抽血用放射免疫法（ＲＩＡ）测孕酮（Ｐ）水平。初步了解ｈＣＧ注射时血孕酮水平与ＩＶＦ－ＥＴ结果的关系。结果：当Ｐ＜０．３５μｇ／Ｌ时，９例中无１例妊娠。而０．３５≤Ｐ≤０．９μｇ／Ｌ组（５４例）与Ｐ＞０．９μｇ／Ｌ组（１５例）的妊娠率分别为２２．６％及２６．７％。但三组间无显著差异。结论：排卵前卵泡分泌微量Ｐ可能有助于ＬＨ峰的释放，担心这种微量Ｐ的升高而提前注射ｈＣＧ是没有必要的，在ｈＣＧ注射前血清Ｐ＜０．３５μｇ／Ｌ妊娠率似有所下降。
Objective: To investigate the relationship between the level of serum progesterone (P) on the day of hCG administration and the outcome of pregancy in women undergoing stimulation with FSH and hMG during GnRH agonist (GnRHa) suppression of pituitary.Design: Seventy-eight women who participated in IVF-ET treatment for infertility were stimulated with standard GnRHa(buserelin)-FSH/hMG-hCG regimen for multiple follicular growth. They were divided into three groups according to their serum levels of progesterone on the day of hCG injection as determined by radioimmunoassay (RIA). Pregnancy rates are compared between different groups.Results: In serum P<0.35μg/L group (n=9), none of the patients were pregnant. In group with serum P level between 0.35μg/L and 0 9μg/L (n=54), and P>0 9μg/L group (n=15), the pregnancy rate was 22 6% and 26.7%, respectively. The pregnancy rates of the latter two groups were higher than that of the first group. However, the differences were not statistically significant. Conclusion: The slight increase in serum P level prior to ovulation may be needed for LH peak release. Therefore, earlier injection of hCG to avoid the slight P rise may be unnecessary. On the contrary, lower serum P level just before hCG injection seems associated with lower pregnancy rate, but further study is needed to reach the conclusion. \ \
出处
《中国实用妇科与产科杂志》
CAS
CSCD
北大核心
1997年第3期147-148,共2页
Chinese Journal of Practical Gynecology and Obstetrics
关键词
体外受精
胚胎移植
孕酮
妊娠率
不育症
In vitro fertilization\ \ Embryo transfer\ \ Progesterone\ \ Pregnancy rate
