摘要
目的:为控制复方可待因药品的质量和非治疗性使用,建立磷酸可待因含量的测定方法。方法:采用气相色谱法(GC)/中空纤维膜-液相微萃取(liquid phase microextraction supposed by hollow fiber membrane,LPME-HFM)测定止咳糖浆中磷酸可待因的含量。结果:磷酸可待因浓度在1.0～50.0μg·mL^(-1)间有良好的线性关系,平均回收率为102.7%,RSD为4.2%。结论:方法简单、快速、微量,灵敏度高,可用于控制药品质量和监管复方可待因止咳药水的滥用。
Objective： To develop a method for determination of codeine phosphate for the quality of codeine solution. Methods：To determine content of codeine phosphate in codeine cough syrup by gas chromatography and hollow fiber liquid phase microextraction. Results：There was good linearity at 1.0 -50. 0 μg·mL^-1 ,the average recovery was 102. 7 %, the relative standard deviation was 4. 2%. Conclusion： The method is simple, fast, sensitive, and is liable to control the quality and the abuse of codeine cough solution.
出处
《药物分析杂志》
CAS
CSCD
北大核心
2007年第11期1738-1741,共4页
Chinese Journal of Pharmaceutical Analysis
基金
2006年度沈阳市大型科学仪器共享研究专项课题资助(200609113)
关键词
复方可待因止咳糖浆
磷酸可待因
气相色谱法
中空纤维膜-液相微萃取
Compaunb codeine cough syrup
codeine phosphate
gas chromatography （ GC ）
liquid phase microextraction supported by hollow fiber membrane（ LPME -HFM）
