摘要
将多孔聚四氟乙烯（PTFE）、聚乙烯（PE）、聚丙烯（PP）制成正极性多孔PTFE／PE／PP驻极体。用改进的Franz扩散池和高效液相色谱仪比较研究多孔PTFE/PE／PP驻极体和不同浓度氮酮对利多卡因的透皮吸收效应．结果显示：（1）lkV多孔PTFE／PE／PP驻极体作用利多卡因24h，其累积渗透量比对照组增加4．57倍；（2）正极性多孔PTFE/PE／PP对利多卡因的增渗效应与其表面电位呈正相关．（3）正极性多孔PTFE／PE／PP驻极体与1％氮酮和5％氮酮联用能显著增加利多卡因的经皮渗透量．
The porous PTFE/PE/PP electret and azone were employed to make the comparative study of lidocaine transdermal enhancement by means of Franz cell and high performance liquid chromatography. The results indicated that （1） lkV porous PTFE/PE/PP electret could increase the 24 h accumulative permeation amount of lidocaine for 4.37 times as compared with that of control group. （2） The enhancing effect of positive electret was related to its surface potential. （3） The combination application of porous PTFE/PE/PP and 1% azone or 5% azone could greatly increase the lidocaine transdermal delivery.
出处
《功能材料》
EI
CAS
CSCD
北大核心
2007年第A05期1698-1701,共4页
Journal of Functional Materials
基金
国家自然科学基金资助项目（50577066）军队“十一五”国际合作课题（06H022）
