摘要
目的:通过对失代偿期肝硬化患者进行幽门螺杆菌根除治疗,探讨其对于预防肝性脑病和上消化道出血的临床意义。方法:从75例幽门螺杆菌阳性失代偿期肝硬化患者中随机选取34例进行幽门螺杆菌根治,观察治疗后一年内血氨、肝功能状况、胃镜检查结果以及发生肝性脑病和上消化道出血的次数,与对照组相比进行统计学分析。结果:两组间发生上消化道出血的次数有差异(P<0.05),而发生肝性脑病的次数无统计学差异(P>0.05)。在试验开始和观察期结束时,治疗组和对照组在血氨、肝功能状况、胃镜检查结果方面无差异。结论:幽门螺杆菌根治对于预防肝性脑病无作用,对于预防上消化道出血有一定意义。
Objective To investigate the long- term effect of H. pylori eradication in decompensation hepatic cirrhosis patients for preventing hepatic encephalopathy and upper gastrointestinal hemorrhage. Methods Thirty - four patients was enrolled randomly from 75 patients with H. pylori - positive and treated with H. pylori eradication. Blood ammonia level and hepatic function situation was measured, gastroscopical examination resuts and frequency of having hepatic encephalopathy and upper gastrointestinal hemorrhage within one year was record. These results were compared in H. pylori eradication group with control group. Results After one year, there was statistically different in frequency of having upper gastrointestinal hemorrhage between treatment group and control group, but there was not significant difference in frequency of having hepatic encephalopathy. Conclusions H. pylori eradication may prevent upper gastrointestinal hemorrhage in decompensation hepatic cirrhosis patients, but it cannot prevent hepatic encephalopathy.
出处
《郧阳医学院学报》
2007年第5期281-283,共3页
Journal of Yunyang Medical College
关键词
幽门螺杆菌
肝硬化
肝性脑病
上消化道出血
Helicobacter pylori
Hepatic cirrhosis
Hepatic encephalopathy
Upper gastrointestinal hemorrhage
