摘要
目的:分析胃肠间质瘤(gastrointestinal stromal tumors,GISTs)临床病理特性及影响预后因素,探讨提高GISTs疗效的有效方法。方法:对随访的68例GISTs患者的临床资料行Kaplan-Meier生存分析。结果:生存分析显示肿瘤直径<5cm、病理核分裂像<5/50HPF、服用格列卫的患者生存率较高,手术治疗行肿瘤完整切除术与扩大切除术生存率差异无统计学意义(P=0.8705)。结论:肿瘤直径、核分裂像与预后有关,完整切除肿瘤可获得根治效果,术后服用格列卫能改善患者预后。
Objective： To investigate the clinical features and prognosis of gastrointestinal stromal tumors （GISTs）. Methods： Sixty-eight cases of GISTs patients were analyzed retrospectively. There were 39 male and 29 female patients in 68 cases who presented a mean age of 54.8 years. The main complaints were abdominal pain （40%）, distention （34%） and mass （30%）. Fifty-eight patients received enbloc resection, while extended removal was carried on others. Fifty-five tumors located in ga^strointestinal duct. Results： Tumor diameters of 36 cases were more than 5 centimeters. Routine pathologic test found spindle tumor cells and karyokinesis cells more than 5/50 HPF in 29 samples. There was 1 patient with lymph node metastasis. The positive rates of immunohistochemical staining of CD117, CD34 and CSMA were 90%, 69% and 30%, respectively.Glivec was given to 46 patients （400 mg/d） for one year at least. Recurrence diseases were found in 12 cases who did not receive Glivec treatment. The survival rates of 3 year and 5 year were 82.3% and 22.1% （15/68）. No difference was found between en bloc resection and extended removal group （P=0.870 5）. Conclusion： The positive staining of CD117 was an important symbol of GISTs, en bloc resection was proved to be an ideal surgical procedure.
出处
《中国现代普通外科进展》
CAS
2007年第5期409-411,共3页
Chinese Journal of Current Advances in General Surgery
关键词
胃肠间质瘤·预后·治疗
Gastrointestinal stromal tumors·Prognosis·Surgical resection
