摘要
检测892例各类肝病患者血清中甲型(HAV)、乙型(HBV)、丙型(HCV)、戊型(HEV)肝炎病毒标志物。丙型肝炎患者占肝病患者13.6%(121/892),其中59.5%(73/121)为重叠感染。HCV与HBV重叠感染最常见,占64.6%(47/73),其次是HCV、HAV和HBV(13.7%),HCV与HEV(18.2%),HCV与HAV(6.8%),及HCV、HBV和HEV(6.8%)。HCV重叠感染者重症肝炎生率及病死率均显著高于单纯HCV感染者。结果提示,重叠感染是HCV感染者病情恶化及死亡的重要因素。
HAV、HBV、HCV and HEV markers were detected in the sera of the 892 patients with liver diseases. The positive rate of HCV marker was 13.6%(121/892). 59.5% of the patients with HCV infection suffered from superinfection. The most common mode of superinfection was HCV and HBV (84.9%). The next modes were as follows; HCV and HAV and HBV (13.7%), HCV and HEV (8.2%), HCV and HAV (6.8%), HCV and HBV and HEV (6.8%) respectively. The morbidity of severe hepatitis and mortality in the patients with HCV superinfection were significantly higher than those in the patients with HCV infection alone. The results suggest superinfection may play an important role in the aggravation and death of patients infected with HCV.
作者
郑齐超
桂稀恩
骆名其
彭淑华
杨自成
梁丽珍
Zheng Qichao;Gui Xien;Luo Mingqi(Department of Infectious diseases.Second Affiliated Hospital,Hubei Medical University,Wuhan 430071,China)
关键词
丙型肝炎
重叠感染
病原分型
预后
hepatitis C
etiologic typing
superinfection
prognosis
