摘要
目的观察复发性脂肪肉瘤术前灌注化疗的疗效。方法21例复发性脂肪肉瘤患者,术前采用皮下埋植式动脉介入化疗系统,用阿霉素和顺铂为主,联合咖啡因治疗。结果病变影像改变有效18例,病理中重度以上化疗反应15例,平均随访39个月,术后肿瘤局部复发2例,肺转移1例,3例死亡。结论复发性脂肪肉瘤的治疗可以选择动脉灌注化疗,肿瘤组织学分类恶性程度高的化疗效果更好,以化疗后手术切除的肿瘤病理改变作为重要的预后评价标准。
Objective To investigate the efficacy of preoperative infusion chemotherapy in treatment of recurrent liposarcoma. Methods Twenty-one patients with recurrent liposareoma received the treatment of preoperative intra-arterial chemotherapy and surgical resection. Intra-arterial chemotherapy was given by subcutaneous implanting drug delivery system with infusion of cisplatin and doxorubicin followed by caffeine. After treatment, the patients were followed up for 39 months. Results The efficacy showed by liposarcoma changes in CT imaging were observed in 18 cases and 15 of them had medium or high-degree pathological changes caused by chemotherapy. At the end of the postoperative follow-up for 39 months, liposarcoma recurred locally in 2 cases,pulmonary metastasis occurred in 1 case and death in 3 cases. Conclusion Preoperative intra-arterial chemotherapy is effective for highly malignant tumors such as recurrent liposarcoma and the judgment of prognosis is based on the postoperative pathological changes of such tumor.
出处
《中国肿瘤临床与康复》
2007年第5期409-411,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
埋植式动脉介入化疗
脂肪肉瘤
咖啡因
Implantable intra-arterial interventional chemotherapy
Liposarcoma
Caffeine
