摘要
目的探讨肺硬化性血管瘤(SHL)的临床病理特点及免疫表型。方法对20例SHL进行光镜及免疫组织化观察。结果SHL主要由园形间质细胞及被覆立方细胞二种细胞类型组成。组织学表现为实性区、乳头区、出血区和硬化区四种结构。免疫组化显示:园形间质细胞和被覆立方细胞共同表达TTF-1和EMA,仅被覆立方细胞表达AE1/AE3和SP-B。结论SHL为起源于原始的呼吸道上皮细胞的肿瘤,园形间质细胞和被覆的立方细胞均为肿瘤细胞,结合组织学特征和免疫标记,有助于SHL的诊断和鉴别诊断。
Objective To investigate sclerosing hemangioma of lung（SHL）. Methods clinicopathologic features and immunophenotype of Twenty cases of SHL were studied by pathologic histology and immunohistochemistry. Results SHL has a characteristic architecture composed of round stromal cells and surface cuboidal cells. It has four histopathologic pattern that contain soild pattern, papillary pattern,hemorrhagic pattern and sclerotic pattern. Immunohistochemically these two kind＇s of cells were both positive for TTF - 1 and EMA, and only surface cuboidal cells were positive for AE1/ AE3 and SP - B. Conclusion SHL is a tumor that orginates from the epithelial cell of primary respiratory tract. Both the round stromal cells and surface cuboidal cells are neoplastic. Morphology and immunophenotype of SHL acts an important role in diagnosis and differential diagnosis.
出处
《医药论坛杂志》
2007年第21期3-5,共3页
Journal of Medical Forum
关键词
肺
硬化性血管瘤
免疫组化
鉴别诊断
Lung
Sclerosing hemangioma
Immunohistochemistry
Differential Diagnosis
