摘要
目的研究心力衰竭患者血胰岛素和糖代谢的变化及其他因素的关系。方法４１例体重指数、血压均在正常范围的心衰患者进行口服葡萄糖耐量试验观察糖负荷前后血糖、胰岛素变化，根据血糖及胰岛素释放曲线下面积计算胰岛素敏感性，将胰岛素敏感性与Ｔ３和血管紧张素Ⅱ水平作相关分析。结果不同病因所致的心衰均存在有糖耐量降低和高胰岛素血症，但以高心病和冠心病组表现更为突出。心衰患者胰岛素敏感性与血浆血管紧张素Ⅱ、空腹胰岛素呈负相关，与Ｔ３，ＬＶＥＦ呈正相关。结论心衰患者存在胰岛素抗性，其机理与心衰时肾素血管紧张素系统活性增加和甲状腺功能降低而发生的糖代谢紊乱和胰岛细胞分泌过多有关。
Aim\ To investigate the changes of plasma insulin(IS) level and glucose tolerance in patients with heart failure(HF).\ Methods\ Blood glucose, insulin and their area under the curve were measured and calculated in OGTT test.\ Results\ There were glucose intolerence and hyperinsulinemia in HF patients in spite of what pathologic cause. The alteration was most prominent in hypertensive and coronary diseases.\ The significant negative correlations between IS sensitivity and plasma angiotensin Ⅱ, the significant positive correlation between IS sensitivity and serum T 3, left ventricular ejection fraction were found in all HF patients.\ Conclusion\ The carbohydrate metabolism disorder and beta cell hypersecreatory may be attributed to the overactivity of renin angiotensin and hypothyroidism in heart failure patients.
出处
《高血压杂志》
CSCD
1997年第1期32-35,共4页
Chinese Journal of Hypertension
关键词
高胰岛素血症
葡萄糖耐量
T3
心力衰竭
hyperinsulinemia
glucose intolerence
T 3
renin angiotensin system
