摘要
研究了４２例骨髓增生异常综合征患者体外ＣＦＵ－ＧＭ、ＣＦＵ－Ｌ培养和细胞遗传学改变。结果显示，患者ＣＦＵ－ＧＭ明显低于正常对照组（Ｐ＜０．０１），但高于再生障碍性贫血（ＡＡ）（Ｐ＜０．０１），ＣＦＵ－Ｌ高于正常对照组和ＡＡ组（Ｐ＜０．０１）。患者５２．４％存在染色体异常，常见为：＋８、－２２、－Ｘ、－Ｙ、－２０、－７／７ｑ－。ＣＦＵ－ＧＭ减低、ＣＦＵ－Ｌ增高和染色体异常者疗效较正常者差。表明ＣＦＵ－ＧＭ、ＣＦＵ－Ｌ体外培养和细胞遗传学检查可作为ＭＤＳ协助诊断和预测疗效的指标之一。
CFU GM, CFU L culture in vitro and cytogenetic techniques were studied in 42 patients with MDS. The results revealed that this level of CFU GM in patients with MDS was significantly lower than that of the normal (P<0.01), but was higher than that of aplastic aneamia (AA) (P<0.01). And CFU L value in the patients was higher than that of the normal control and AA (P<0.01), clonal abnormal karyotypes were found in 52.4% of MDS. The common chromosomal alterations were +8、-20、-22、-x、-y、-7/7q -. The patients with a reduction of CFU GM、 an increase in CFU L or chromosomal alterations responded less than the normal. The data indicated that CFU GM、CFU L culture in vitro and cytogenetic techniques might be used as a marker for diagnosis and the results of treatment.
基金
胡应洲基金
关键词
骨髓增生异常
综合征
祖细胞培养
染色体
Myelodysplastic Syndrome Hematopoietic progenitor cell Entrinsic culture Chromosome
