摘要
目的探讨基质金属蛋白酶-9（MMP-9）、血管内皮细胞生长因子（VEGF）的表达与肾细胞癌血管生成及生物学特性关系。方法应用免疫组化SP法检测78例肾癌MMP-9、VEGF的表达及微血管密度（MVD）。结果MMP-9在浸润进展期肾癌组（T3～T4）的阳性表达率为87%，明显高于局限性肾癌组（T1～T2）的50%（P〈0.01）；MMP-9和VEGF同时表达阳性者，其血管密度为140.86±24.87，明显高于仅MMP-9或VEGF表达阳性的：99.3±47.97（P〈0.01），亦明显高于二者都表达阴性的：80.16±33.83（P〈0.0001）；肾癌MMP-9、VEGF的表达呈显著性正相关（r=0.40966，P〈0.001），MMP-9、VEGF在肾癌的血管生成中有协同作用。结论MMP-9、VEGF联合检出有助于预测肾癌侵袭和转移。
Objective To study the expressions of matrix metalloproteinase-9 （MMP-9）, vascular endothelial growth factor （VEGF） and their correlation with angiogenesis and biological behaviour in renal cell carcinoma（RCC）. Methods The expressions of MMP-9 ,VEGF and CD34 were detected by means of immunohistochemistry in 78 cases of RCC. Results The positive expression rate of MMP-9 was 87% in the high staging group and 50% in the low staging group,the statistical significance existed between the two groups （P〈0.01） ;the MVD was 140.86±24.87 in both positive expressions of MMP-9 and VEGF, was higher than that in the single positive ones（99.3±47.97）（P±0.01）and the both negative ones （80. 16±33.83）（P〈0. 000 1）. The expression of MMP-9 correlated with VEGF in renal cell carcinoma（r=0. 409 66, P〈O. 01）. Conclusion MMP-9 and VEGF may serve as biological predictor for tumor metastatic potential in renal cell carcinoma.
出处
《重庆医学》
CAS
CSCD
2007年第13期1298-1300,共3页
Chongqing medicine
