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人类乳头瘤病毒(HPV)的检测方法 被引量:5

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摘要 宫颈癌是最常见的妇科恶性肿瘤之一.占女性生殖系统恶性肿瘤的半数以上,严重威胁着妇女的健康。全世界每年大约有46万人患病.中国新发病例约计13万,占目前已发现的所有女性肿瘤的6%.是仅次于乳腺癌而引起妇女癌症相关死亡的重要原因。宫颈癌的发病机理目前尚不清楚.但已有很多研究证明,99%的宫颈癌组织中可检出人乳头瘤病毒(humanpapillomavirus,HPV)。目前,已经明确HPV感染为宫颈癌前病变和浸润性宫颈癌发生的必要条件。大量研究资料表明,HPV与宫颈癌及癌前病变密切相关,高危型HPV(HRHPV)感染与宫颈癌关系最为密切。随着病变程度的加重,HPV的检出率也逐渐增高。所以,许多专家提出将HPV的检测作为宫颈癌的一种筛查手段。目前,针对HPVDNA检测作为宫颈癌原始筛查方法以及与细胞学联合在筛查中的意义的研究报道较多。本文将就HPV检测方法的相关内容进行小结.重点介绍目前应用最为广泛的PCR法和杂交捕获试验。
出处 《现代预防医学》 CAS 北大核心 2007年第22期4270-4271,共2页 Modern Preventive Medicine
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