摘要
为比较尿激酶（UK）及组织型纤溶酶原激活剂（t-PA）静脉溶栓辅以阿司匹林及肝素对急性心肌梗塞的效果及其副作用。对急性心肌梗塞患者发病6h内者，42例给予静脉UK15例静脉内t-PA溶栓辅以静脉肝素及阿司匹林治疗。结果表明，t-PA组、UK组临床血管再通率分别为86．7％与57．1％（P＜0．05），前者消化道与呼吸道出血并发症为13．3％，而后者为0（P＜0．05）。本研究提示静脉t-PA溶栓血管再通率显著高于静脉UK，但出血合并症的发生t-PA组显著高于UK组。
To compare the effectiveness and complications of intravenous Urokinase (UK) and tissue plasminogen activator (t-PA) plus intravenous heparin and Aspirin in patients with acute myocardial infarction (AMI). 15 patients in t-PA group and 42 patients in UK group were included in the study, and either of them were simultaneously treated with intravenous UK t-PA plus intravenous heparin and Aspirin. The clinical reperfusion rates in t-PA and UK group were 86. 7% and 57. 1 % (P<0.05),respectively. The major bleeding complications including respiratory and gastrointestinal bleeding in t-PA group were significantly higher than that in UK group (13. 3% vs 0,P<0. 05). One patients had hemorrhagic stroke in t-PA group and none in UK group. The patients with AMI treated with intravenous t-PA within 6 hours after onset of symptoms had significant higher reperfusion rate than those treated with intravenous UK, but hemorrhagic complications were siginificantly higher in t-PA group.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
1997年第3期139-141,共3页
Journal of Clinical Cardiology
关键词
尿激酶
纤溶酶原激活剂
静脉溶栓
急性
心肌梗塞
Urokinase
Tissue plasminogen activator
Intravenous thrombolytic therapy
Acute myocardial infarction
