摘要
为了探讨一氧化氮（NO）和肿瘤坏死因子α（TNF-α）在扩张型心肌病（DCM）患者血清中含量变化关系及其意义，分别应用比色法和酶联免疫法测定30例DCM患者血清NO及TNF-α水平，结果显示：DCM患者血清NO及TNF-α较对照组均显著增高（均P＜0．01），且NO与TNF-α间有显著正相关性（r＝0．482，P＜0．01）。表明：高浓度的TNF-α可促进NO的合成，二者均与DCM的病理生理改变关系密切。
In order to study the changeable correlation and its significance between the serum nitric oxide (NO) and tumor necrosis factor-α(TNF-α) in patients with idiopathic dilated cardiomyopathy (DCM). The serum NO and TNF-α were measured in 30 patients with DCM and 40 normals by colorimetry and enzyme immunosorbent assay respectively. The results showed:the serum NO and TNF-α were all sinificantly increased than the contrast group (all P<0. 01) and there was positive correlation beteen NO and TNF-α (P<0. 01 ). Conclution: The high level of TNF-α can promote the production of NO,both NO and TNF-α may play important roles in the pathophysiologic changes of DCM.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
1997年第3期134-135,共2页
Journal of Clinical Cardiology
