摘要
目的探讨妊娠期肝内胆汁淤积症与围生儿预后的相关因素.方法回顾性分析92例妊娠期肝内胆汁淤积症患者的临床及实验室指标与围生儿预后的关系.结果发病时间<28周,转氨酶伴胆红素升高,高浓度胆汁酸组的早产率、羊水粪染率、新生儿窒息率、死亡率显著高于发病时间>28周,与低浓度胆酸、肝功能正常组比有显著差异(P<0.05).结论妊娠肝内胆汁淤积症发病早,高浓度胆汁酸伴胆红素、转氨酶同时升高是围生儿预后不良的相关因素。
Objective To investigate the correlative factors between intrahepatic cholestasis of pregnancy and the Perinatal- prognosis. Methods The relationship between the clinical and experimental index and the perinatal prognosis in 92 patients with intrahepatic cholestasis of pregnancy was analyzed retrospectively. Resuits The rates of premature infants, meconium - contaminated amniotic fluid, fetal distress and mortality in the group with pathogenic time less than 28w and hepatic function abnormity were significantly higher than those in the contrast group （P 〈 0. 05 ）. Conclusion Early pathogenic time and the high serum total bile acid, transaminase and bilirubin in ICP can all influence the perinatal prognosis.
出处
《昆明医学院学报》
2007年第5期60-63,共4页
Journal of Kunming Medical College
关键词
妊娠
肝内胆汁淤积症
围生儿
预后
Pregnancy
Intrahepatic cholestasis
Perinatal
Prognosis
