摘要
目的:探讨雌激素受体(ER)、孕激素受体(PR)和正常T细胞表达和分泌调节活化因子(RANTES)在子宫腺肌病(adenomyosis)多因素发生、发展机制中的作用。方法:采用免疫组织化学链霉素抗生物素蛋白-过氧化酶连接法(SP法),检测正常子宫内膜30例、子宫腺肌病在位内膜51例和异位内膜51例的ER、PR和RANTES蛋白的表达。结果:①ER、PR的表达:异位子宫内膜组的阳性表达率及表达强度低于正常子宫内膜组和在位子宫内膜组(P<0.01);②RANTES的表达:异位子宫内膜组的阳性表达率及表达强度高于正常子宫内膜组和在位子宫内膜组(P<0.01)。结论:ER、PR在子宫腺肌病组织的表达具有相关性。ER、PR和RANTES的异常表达可能在子宫腺肌病的发病中起一定作用。
Objective ： To detect the expression of estrogen receptor （ER）, progesterone receptor（PR） and RANTES for exploring the multiple factors and mechanism in adenomyosis. Methods ： The expression of ER, PR and RANTES in 30 normal subjects, 51 eutopic and 51 ectopic in adenomayotic tissues was detected by using immunohistochemical streptavidin-biotin peroxidase（SP） method. Results ： The expression of ER and PR in ectopic was lower than that in normal and eutopic adenomyotic tissue, which showed significant difference （ P 〈 0.01 ）, but the expression of RANTES in ectopic was higher than that in normal and eutopic adenomyotic tissue （P 〈 0.01 ）. Conclusion ： The findings suggest that abnormal expression of ER, PR and RANTES may be the mechanism of adenomyosis.
出处
《皖南医学院学报》
CAS
2007年第4期264-266,共3页
Journal of Wannan Medical College
