摘要
目的:探讨事件相关电位P300在功能性消化不良患者中的变化和意义。方法:对27例FD患者和27例健康对照者应用汉密尔顿抑郁焦虑量表、FD主要症状评分表评分和脑电生理仪测定事件相关电位P300,对FD组经四周心理介入(小剂量阿米替林和心理疏导)治疗后,应用上述方法再次评测。结果:FD患者事件相关电位P300较健康对照者P3潜伏期延长(P<0.05)、P3波幅降低(P<0.05),FD患者抑郁焦虑量表评分和主要临床症状评分较健康对照组均高并有差异(P<0.05),FD患者焦虑抑郁评分与P3潜伏期、临床症状评分呈正相关(P<0.01)。FD患者焦虑抑郁评分与P3波幅呈负相关(P<0.01)。心理介入治疗后事件相关电位P300、抑郁焦虑量表评分和主要临床症状评分均明显改善。结论:伴有焦虑抑郁FD患者有认知功能障碍,认知功能可能介入FD发病机制。
Objective：To investigate the change of event-related potentials P300 and its significance in patients with functional dyspepsia （FD）. Methods： Hamilton anxiety scale（HAMA）and Hamilton depression scale （MD）were employed to assess psychological factors and event-related potentials P300, recorded with Oxford MedeleeSynergy while clinical symptoms were estimated with clinical symptoms scoring scheme in 27 patients with FD and 27 healthy control subjects. Psychological factors, event-related potentials P300 and clinical symptoms were measured with above methods in patients with FD in a duration of four weeks of intervene-psychotherapy （small dose of amitriptyline and psychological counseling）. Results ： P3 Iatencies were significantly extended and P3 amplitudes were significantly lower in FD patients than those of controls （P 〈 0.05 ）. The scores of HAMA, HAMD and clinical symptoms scoring in FD patients marked higher than those of controls （P 〈 0.05）. The results suggested that there was direct correlation among the scores of HAMA and HAMD, P3 latencies and the scores of clinical symptoms ,scoring in patients with FD, but the scores of HAMA and HAMD were correlated inversely with P3 amplitudes. There was a great improvement in event-related potentials P300, scoring of psychological factors and clinical symptoms in four-week of intervene-psychotherapy in FD patients. Conclusion ： The fact that FD patients with anxiety and depression complicating with cognitive deficits suggests that cognitive process may be involved in the pathogenesis.
出处
《皖南医学院学报》
CAS
2007年第4期257-260,共4页
Journal of Wannan Medical College
基金
安徽省教育厅自然科学基金项目(2006KJ409B)
