摘要
本研究目的是了解长期服用小剂量米非司酮对子宫肌瘤患者的子宫内膜的影响。２０名有症状的子宫肌瘤患者连续服用三个月米非司酮（１０ｍｇ／ｄ）后行子宫全切术，取子宫内膜做常规病理检查。治疗前和治疗期间每月定时测量子宫和肌瘤体积，同时测定内分泌激素。结果显示：肌瘤的体积平均缩小了４１．４％（Ｐ＜０．０１）；所有治疗组病人的子宫内膜形态异常，内膜腺体的大小和形态不规则，间质差异较大，未见不典型增生。血ＬＨ升高，ＦＳＨ降低，Ｅ２、Ｐ为卵泡早期到中期水平。结论为整个子宫内膜的变化与长期处于由米非司酮所引起非拮抗性雌激素环境相一致，同时也可以看到米非司酮对子宫内膜具有弱的孕激素影响。
To examine endometrial response to long-term low-dose mifepristone administration, 20 patients with leiomyomata were treated with 10mg mifepristone daily for 3 months then underwent hysterectomy. Endometrium tissue was obtained at surgery for histological examination after treatment. Hormonal bioassays were taken before treatment and every month during the therapy. Our results showed that abnormal endometrial morphology was exhibited in all patients. The endometrial glands were irregular in size and shape. The stroma was varied. The glands were lined by a combination of epithelial types some of which were in secretory phase.No cytologic atypia was seen.Plasma follicular stimulate hormone were at low level. The level of Luteinzed hormone increased. No apparent change in estrogen and progesterone level remained the concentrations seen in the early to midfollicular phase range. The generalized cystic changes of endometrium are consistent with a chronic unopposed estrogen effect and estrogen level remaining in early to midfollicular phase. In some area of endometrium weak progesterone agonist effect was noted.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
1997年第2期78-81,共4页
The Chinese Journal of Clinical Pharmacology
关键词
米非司酮
子宫内膜
子宫肌瘤
剂量
mifepristone
endometrium
pathology
hormone assay
