摘要
目的通过热分析技术证实共熔体的形成。方法按照差示扫描量热分析(DSC)和热重分析(TG)方法分别测定乳糖、格列齐特以及乳糖和格列齐特不同比例混合样。结果DSC曲线和TG曲线证明乳糖和格列齐特一定比例下形成共熔体。结论乳糖和格列齐特一定比例下经高速研磨混合的样品形成了共熔体;采用该工艺技术可显著提高难溶性药物主药格列齐特的溶出速率。
Objective To illustrate the preparation of Gliclazide dispersible tablets by thermoanalysis technology. Methods To determine Galactosylglucose, Gliclazide and the different proportion of Galactosylglucose and Gliclazide according to the methods of different scanning colorimetry（DSC） and mogravimetry（TG）, Results From the graphs of DSC and TG , solid dispersion was formed in the procedure. Conclusion The sample of Galactosylglucose and Gliclazide can form solid dispersion by high speed grinding. The dissolution rate of Gliclazide can be significantly improved by this technology.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2007年第11期2797-2798,共2页
Lishizhen Medicine and Materia Medica Research
