摘要
目的研究聚壳聚糖-丙烯酸磁性微球的制备过程以及性能测试。方法实验运用反相乳液聚合法，以环已烷为油相，壳聚糖-丙烯酸溶液为水相，过硫酸钾为引发剂，十二烷基硫酸钠为分散剂，戊二醛为交联剂，司班80为乳化剂，并加入磁流体，在60℃水浴下，机械搅拌，反应数小时，抽滤，洗涤，干燥，制得微球。结果当壳聚糖用量为2g，质量浓度为50mg/ml的丙烯酸用量为100ml时反应效果最好，溶液最为均匀，反应效果最佳。最后用扫描电镜对磁性微球进行形态观察和结构表征测试。微球外表呈较均匀的圆球状，粒径大约在55～100nm之间。结论基本属于纳米磁性微球。
Objective This study introduced synthesis and characteristics of Polychitosan - acrylic acid magnetic microspheres. Methods Magnetic polychitosan - acrylic acid microspheres were prepared by reversed phase with Chitosan - acrylic acid solution as water phase , K2S2Os as initiator , CH3 （ CH2 ）11OSO3 Na as dispersant, glutaraldehyde as cross - linker keep water area temperature at 60℃. After percolated, syringed, desiccated, the magnetic micropheres were got. Results The best dosage of reactants was chitosan 2 g and acrylic acid 100 ml（ 50 mg/ml）. The results demonstrated that microspheres were almost sphericity and size distribution was around 55 - 100 nm by SEM. Conclusion The products belong to nano magnetic microsopheres.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2007年第11期2793-2795,共3页
Lishizhen Medicine and Materia Medica Research
关键词
聚壳聚糖-丙烯酸
磁性微球
反相乳液聚合
Polychitosan -acrylicacid
Magnetic microspheres
Reversed phase emulsion polymerization
