摘要
目的本研究通过对烧伤创面细菌学调查及耐药性分析,为临床治疗提供参考。方法从2004年1月至2007年4月本院收治的69例烧伤患者创面细菌培养分离出细菌170株,用纸片琼脂扩散法进行药物敏感试验,就其中前5种细菌进行回顾性分析。结果在本组检出的细菌中,革兰阴性杆(G^-)菌122株(71.76%),革兰阳性(G^+)菌48株(28.24%)。其中,数量较多的前5种细菌为鲍曼不动杆菌(17.00%),阴沟肠杆菌(11.18%),铜绿假单胞菌(10.00%),金黄色葡萄球菌(10.59%),肺炎克雷伯菌(8.82%)。鲍曼不动杆菌占G^-杆菌的23.77%,该菌对几乎所有抗菌药物耐药,对亚胺培南的耐药率高达75.86%。阴沟肠杆菌占G^-杆菌的15.57%,对抗菌药物的耐药率超过90%,对亚胺培南敏感。铜绿假单胞菌和肺炎克雷伯菌对抗菌药物的耐药率超过50%。金黄色葡萄球菌占G^+菌的37.5%,对万古霉素的耐药率为17.65%。以上5种细菌对大多数常用抗菌药物表现出高耐药性。结论本组烧伤患者感染细菌以G^-杆菌为主,G^+菌次之,这些细菌对常用抗菌药物有多重耐药性,亚胺培南对大多数G^-杆菌仍有较高的抗菌活性。G^+菌对万古霉素敏感。
Objective To investigate bacteria on burn wounds and the results of drug resistance tests. Methods Retrospective investigation was done to 69 burn patients who were treated from the January of 2004 to the April of 2007 in the Department of Burn and Plastic Surgery, First People＇ s Hospital, Yibin City, Sichuan. 170 strains of bacteria were isolated from the wounds and the dick diffusion method was used to determine drug resistance. Results Totally, 122 strains of gram-negative bacteria （71.76%） and 48 stains of gram-positive bacteria （28.24%） were isolated. Among them, the five bacteria identified most often were baumanii （ 17.00% ）, Enterobacter cloacae （ 11.18% ）, Pseudomonas aeruginosa （ 10.00% ）, Staphylococcus aureus （ 10.59% ） ,and Klebsiella pneumoniae （8.82%）. Baumanii made up 23.77% of all the gram-negative bacteria and were tolerant to most antibiotics. Its resistance rate to imipenem was as high as 75.86%. Enterobacter cloacae made up 15.57% of all the gram-negative bacteria and had a high rate （90%） of drug resistance to most antibiotics excluding imipenem. To most antibiotics, Pseudomonas aeruginosa and Klebsiella pneumoniae had a resistance rate of over 50%. Staphylococcus aureus made up 37.5% of the grampositive bacteria and had a rate of 17.65% for vancomycin tolerance. Conclusions Gram-positive bacteria are responsible for most burn wound infections. Bacteria related to burn wound infections are resistant to commonly used antibiotics. Imipenem has comparatively high antibacterial activity to most gram-negative bacteria, and vancomycin is effective to gram-positive bacteria.
出处
《中华损伤与修复杂志（电子版）》
CAS
2007年第2期94-97,共4页
Chinese Journal of Injury Repair and Wound Healing(Electronic Edition)
关键词
烧伤创面
细菌培养
耐药性
Burn wound
Bacterial culture
Drug resistance
