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作用于细菌蛋白质合成的全合成抗菌剂研究进展 被引量：7

Progress of Research on Antibacterial Agents Inhibiting Bacterial Protein Synthesis
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摘要 肽脱甲酰基酶抑制剂和噁唑烷酮类抗菌剂是近年来新型全合成抗菌药的研究热点,它们都作用于细菌蛋白质的合成。本文综述了这两类抗菌剂近年来结构修饰及构效关系的研究进展,为进一步的新药研究提供参考。 Both the inhibitors of peptide deformylase and oxazolidinones are the foci on the research of novel totally-synthesized antibacterial agents which function by blocking the protein synthesis in bacterial cells. In the paper, the structural modification and structure-activity relationship of these two types of antibacterials are reviewed in order to give some references for the further research.
作者 周伟澄
机构地区 上海医药工业研究院
出处 《中国医药工业杂志》 CAS CSCD 北大核心 2007年第11期805-813,共9页 Chinese Journal of Pharmaceuticals
基金 上海市科委基金(07DZ22002 07XD14205)
关键词 肽脱甲酰基酶 抑制剂 噁唑烷酮 抗菌剂 蛋白质合成 综述 peptide deformylase inhibitor oxazolidinone antibacterial protein synthesis review
分类号 R978 [医药卫生—药品]
  • 相关文献

参考文献45

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二级参考文献110

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共引文献19

同被引文献92

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  • 2翟鑫,汪玉梅,宫平.新型噁唑烷酮类抗菌药物的研究进展[J].沈阳药科大学学报,2006,23(11):739-744. 被引量：5
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引证文献7

二级引证文献38

中国医药工业杂志
2007年 第11期

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